Glycemic Control, Brain Structure and Cognition in Youth With Type 1 Diabetes (T1DM)
| Status: | Recruiting |
|---|---|
| Conditions: | Cognitive Studies, Diabetes |
| Therapuetic Areas: | Endocrinology, Psychiatry / Psychology |
| Healthy: | No |
| Age Range: | 7 - 16 |
| Updated: | 4/21/2016 |
| Start Date: | November 2008 |
| End Date: | November 2016 |
| Contact: | Angie Starnes, RN |
| Email: | starnesa@kids.wustl.edu |
| Phone: | 314-286-1107 |
Glycemic Control, Brain Structure and Cognition in Youth With T1DM
LO5 study: The investigators are inviting a new group of youth (ages 7-16) who have been
recently diagnosed with type 1 diabetes and their non-diabetic siblings. These youth will
complete cognitive tests and a MRI scan of the brain. This scan uses strong magnets to
obtain pictures and does not involve any radiation or injections. The investigators will
recruit patients within three months of their diagnosis date. The study entails 1 study
visit that lasts 3.5 hours. Evening and weekend times are available. The investigators plan
to enroll 135 participants.
HY5 study: The investigators are inviting a cohort of youth and young adults (ages 9-21)
with type 1 diabetes and their non-diabetic siblings for a follow-up to a study they have
already completed. This group of people will complete several memory and thinking tests
along with several MRI scans of their brain, just as they did at their previous visits. The
investigators plan to enroll 150 participants.
recently diagnosed with type 1 diabetes and their non-diabetic siblings. These youth will
complete cognitive tests and a MRI scan of the brain. This scan uses strong magnets to
obtain pictures and does not involve any radiation or injections. The investigators will
recruit patients within three months of their diagnosis date. The study entails 1 study
visit that lasts 3.5 hours. Evening and weekend times are available. The investigators plan
to enroll 135 participants.
HY5 study: The investigators are inviting a cohort of youth and young adults (ages 9-21)
with type 1 diabetes and their non-diabetic siblings for a follow-up to a study they have
already completed. This group of people will complete several memory and thinking tests
along with several MRI scans of their brain, just as they did at their previous visits. The
investigators plan to enroll 150 participants.
LO5:
Inclusion Criteria for Participants with Type 1 Diabetes:
- Between the ages of 7 and 16
- Diagnosed with type 1 diabetes within 3 months
Inclusion Criteria for Participants without Type 1 Diabetes:
- Between the ages of 7 and 16
Exclusion Criteria for Participants with Type 1 Diabetes:
- Pregnant or lactating
- Chronic disease other than T1DM, well-controlled asthma, or Hashimoto's thyroiditis
- Other current serious medical illness
- Psychiatric illness
- Psychoactive drug dependence
- Neurological illness (except T1DM-related): stroke, seizure, major loss of
consciousness, head injuries, encephalitis, or hydrocephalus, blindness, deafness
- Use of psychoactive medications or exposure to neuroleptics (except that exposures of
less than 1 month, occurring more than 5 years ago, will be allowed)
- Use of dopamine depleting agents or stimulants such as Ritalin, Cylert, Adderall
- Pre-maturity at birth of more than 4 wks early with complications (e.g. on respirator
at NICU)
- Inability to complete MRI scan (e.g. claustrophobia, metal implants)
- Full set (top and bottom) of orthodontic braces (Half set braces, fillings, and
retainers are OK)
Exclusion Criteria for Participants without Type 1 Diabetes:
- Same as above (except cannot have type 1 diabetes)
HY5: Must have been a participant in our earlier study.
We found this trial at
1
site
St. Louis, Missouri 63108
Principal Investigator: Tamara G Hershey, PhD
Phone: 314-286-1107
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