A Trial In Patients With Advanced Cancer And Leukemia

Status:	Completed
Conditions:	Cancer, Blood Cancer
Therapuetic Areas:	Oncology
Healthy:	No
Age Range:	16 - Any
Updated:	11/2/2017
Start Date:	June 2009
End Date:	November 2016

A Phase I Trial Of Pf-03084014 In Patients With Advanced Solid Tumor Malignancy And T-cell Acute Lymphoblastic Leukemia/Lymphoblastic Lymphoma

This is a phase 1, dose escalating study to determine the safety of PF-03084014 in patients
with advanced cancer and leukemia

Inclusion Criteria:

- Patients with advanced cancer that is resistant to standard therapy or for which no
standard therapy is available

- Patients with acute T cell leukemia/lymphoblastic lymphoma that is resistant to
standard therapy or for which no standard therapy is available

- Men and women >16 years old

Exclusion Criteria:

- Prior treatment with a gamma secretase inhibitor for treatment of cancer

- Patients taking Tamoxifen

- Patients with active graft versus host disease

- Known human immunodeficiency virus (HIV) or acquired immunodeficiency syndrome (AIDS)
related illness

- Patients who are pregnant or breast feeding

- Patients with clinical evidence of central nervous system disease

We found this trial at

sites

University of Texas M.D. Anderson Cancer Center

1515 Holcombe Blvd
Houston, Texas 77030

713-792-2121