Pharmacotoxicology of Trichloroethylene Metabolites: Kinetic Study of Dichloroacetate (DCA) in Persons Homozygous for KRT Versus Wildtype
| Status: | Archived |
|---|---|
| Conditions: | Healthy Studies |
| Therapuetic Areas: | Other |
| Healthy: | No |
| Age Range: | Any |
| Updated: | 7/1/2011 |
| Start Date: | February 2008 |
| End Date: | February 2011 |
Pharmacotoxicology of Trichloroethylene Metabolites: Kinetic Study of DCA in Persons Homozygous for KRT vs Wildtype
Specific Aim 2: Establish the relationship between human MAAI haplotype and DCA and
tyrosine metabolism. This aim tests the postulates that MAAI haplotype determines 1)
dose-dependent DCA kinetics and biotransformation and 2) DCA's effects on tyrosine
metabolism. Population pharmacogenetic analysis of MAAI allelic frequencies and GC or
LC-MS/MS techniques for blood or urinary metabolites will be used in these investigations.
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