Effect of Diet-induced Weight Loss on HIV-associated Metabolic Syndrome



Status:Completed
Conditions:HIV / AIDS, Endocrine
Therapuetic Areas:Endocrinology, Immunology / Infectious Diseases
Healthy:No
Age Range:18 - 60
Updated:11/30/2013
Start Date:February 2009
End Date:July 2011
Contact:Sherry Lassa-Claxton
Email:lassa-claxton@WUSTL.EDU
Phone:314 362-7637

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Trial Summary
Trial Overview
Inclusion Criteria

Obese HIV-positive women with Metabolic Syndrome (HIV-MS) and obese HIV-negative women with
Metabolic Syndrome will be studied before and after achieving moderate (6%-8%) diet-induced
weight loss. The investigators hypothesize that health markers will improve in both groups
but that the improvement will be blunted in the women with HIV-MS.


Inclusion Criteria:

- Sedentary

- Obese

- Have either dyslipidemia (HDL < 50 or triglycerides > 150), waist circumference >
88cm, and impaired glucose tolerance or homeostasis model assessment value of > 3

- Subjects with HIV-MS must have been receiving HAART for > 6 months

Exclusion Criteria:

- Medication changes in the last 3 months

- Diabetes mellitus

- Medical problems that in the opinion of the principal investigator may interfere with
patient safety

- Substance abuse
We found this trial at
1
site
Washington University School of Medicine
660 S Euclid Ave
Saint Louis, Missouri 63110
(314) 362-5000
Washington University School of Medicine Washington University Physicians is the clinical practice of the School...
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from
Saint Louis, MO
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