The Effect of Testosterone Replacement on Bone Mineral Density in Boys and Men With Anorexia Nervosa
| Status: | Archived |
|---|---|
| Conditions: | Orthopedic, Psychiatric |
| Therapuetic Areas: | Psychiatry / Psychology, Orthopedics / Podiatry |
| Healthy: | No |
| Age Range: | Any |
| Updated: | 7/1/2011 |
| Start Date: | December 2008 |
| End Date: | December 2010 |
The Effect of Testosterone Replacement on Bone Mineral Density and Bone Microarchitecture in Teenage Boys and Young Adult Men With Anorexia Nervosa
Decreased bone strength is a common and serious medical problem present in many people with
anorexia nervosa. Men with anorexia nervosa have lower levels of gonadal steroids such as
testosterone. Low testosterone levels have been shown to result in low bone density.
We are investigating whether bone mineral density and bone microarchitecture are abnormal in
males with anorexia nervosa and whether supplementation with testosterone would improve both
bone mineral density and bone microarchitecture.
Low bone mineral density is a co-morbidity associated with anorexia nervosa that has been
shown to persist even after weight gain. Peak bone mass accrual occurs during the
adolescent years, and a disruption in this critical process increases the risk for
developing persistent deficits in bone density, and possibly increased fracture risk.
Multiple variables contribute to the bone mass accrual process in puberty including adequate
levels of sex hormones and puberty specific changes in levels of these hormones. Teenage
boys with anorexia nervosa have lower bone density than normal weight boys of comparable
maturity, and also have decreased levels of testosterone, as well as estradiol, when
compared with healthy controls. Although testosterone is an important predictor of bone
density in males with anorexia nervosa, the effect of testosterone replacement on bone mass
accrual and bone microarchitecture in hypogonadal teenage boys and young adult men with
anorexia nervosa is unknown. We hypothesize both bone mass and bone microarchitecture are
abnormal in anorexia nervosa and that testosterone replacement in adolescent males with
anorexia nervosa will improve both bone mass and microarchitecture.
We found this trial at
1
site
Click here to add this to my saved trials
