Genetic Susceptibility to Bladder Cancer



Status:Recruiting
Conditions:Cancer, Cancer, Healthy Studies, Other Indications, Bladder Cancer
Therapuetic Areas:Oncology, Other
Healthy:No
Age Range:Any
Updated:9/13/2018
Start Date:February 10, 1998
End Date:August 2019
Contact:Jian Gu, MD
Email:jiangu@mdanderson.org
Phone:713-792-3020

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Genetic Susceptibility to Bladder Cancer: A Molecular Epidemiology Approach

This clinical research study will identify biologic and lifestyle factors which increase a
person's risk of developing specific cancer. Researchers propose to conduct a case-control
study examining interindividual differences in susceptibility to tobacco carcinogenesis as
predictors of bladder cancer risk. We will measure susceptibility to tobacco carcinogenesis
and this will include studies of the genetic modulation of carcinogen activation and
detoxification and of chromosome sensitivity to tobacco mutagens.

Researchers propose to conduct a case-control study examining interindividual differences in
susceptibility to tobacco carcinogenesis as predictors of bladder cancer risk. We will
measure susceptibility to tobacco carcinogenesis and this will include studies of the genetic
modulation of carcinogen activation and detoxification and of chromosome sensitivity to
tobacco mutagens.

Inclusion Criteria:

- Subject has a histologically confirmed diagnosis of superficial or muscle-invasive
bladder cancer

- Subject is a Texas resident.

- Subject can understand English or a qualified translator is available for the
interview.

- Subjects of any age, gender, or ethnicity are eligible to participate in the study.

- Subject consents to participate in the study.

Exclusion Criteria:

- Subject has had prior treatment with systemic chemotherapy or radiotherapy in the past
6 months.

- Subject has been diagnosed with superficial or muscle-invasive bladder cancer more
than twelve months ago.
We found this trial at
2
sites
1200 Moursund Street
Houston, Texas 77030
(713) 798-4951
Baylor College of Medicine Baylor College of Medicine in Houston, the only private medical school...
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Houston, Texas 77030
Phone: 713-792-3020
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Houston, TX
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