Anidulafungin Versus Fluconazole for the Prevention of Fungal Infections in Liver Transplant Recipients



Status:Archived
Conditions:Infectious Disease, Neurology, Pulmonary
Therapuetic Areas:Immunology / Infectious Diseases, Neurology, Pulmonary / Respiratory Diseases
Healthy:No
Age Range:Any
Updated:7/1/2011
Start Date:February 2010
End Date:December 2012

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Anidulafungin Versus Fluconazole for the Prevention of Invasive Fungal Infections in High-risk Liver Transplant Recipients: a Randomized, Double-blind Trial


The purpose of this study is to compare the efficacy of anidulafungin versus fluconazole for
the prevention of fungal diseases in liver transplant recipients


A number of well characterized risk factors have been shown to portend a high risk of
opportunistic mycoses after liver transplantation.

Retransplantation and renal failure are amongst the most significant risk factors for
invasive fungal infections in these patients.

Most Invasive fungal infections in these high-risk patients occur within the first month
posttransplant.

Studies utilizing universal prophylaxis have primarily employed fluconazole. A recent
meta-analysis of prophylactic trials documented a beneficial effect on morbidity and
attributable mortality, but an emergence of infections due to non-albicans Candida spp. in
patients receiving prophylaxis.

The availability of echinocandins has led to an expanded armamentarium of antifungal drugs
with a potentially promising role as agents for targeted prophylaxis for invasive fungal
infections in high-risk liver transplant recipients. Anidulafungin is unique amongst
echinocandins in that it is eliminated from the body almost exclusively through
biotransformation by slow non-enzymatic degradation in the blood, without hepatic metabolism
or renal elimination. Anidulafungin has demonstrated good safety profile. We hypothesize
that anidulafungin will be more effective and a better tolerated antifungal prophylactic
agent in this setting.


We found this trial at
6
sites
1400 NW 12th Ave
Miami, Florida 33136
(305) 689-5511
University of Miami Hospital The University of Miami changed the face of modern health care...
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Miami, FL
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1500 E Medical Center Dr
Ann Arbor, Michigan 48109
(734) 936-4000
University of Michigan Health Systems The University of Michigan is home to one of the...
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Ann Arbor, MI
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4200 Fifth Ave
Pittsburgh, Pennsylvania 15260
(412) 624-4141
University of Pittsburgh The University of Pittsburgh is a state-related research university, founded as the...
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Pittsburgh, PA
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10833 Le Conte Ave
Los Angeles, California 90095
(310) 825-4321
David Geffen School of Medicine, UCLA In 2002 Mr. David Geffen announced a $200 million...
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Los Angeles, CA
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Madison, Wisconsin 53706
(608) 263-2400
University of Wisconsin-Madison In achievement and prestige, the University of Wisconsin-Madison has long been recognized...
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Madison, WI
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1959 NE Pacific St
Seattle, Washington 98195
(206) 598-3300
University of Washington Medical Center University of Washington Medical Center is one of the nation's...
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Seattle, WA
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