Neuroendocrine Mechanisms of Growth and Body Composition in Preterm and Term Infants
| Status: | Completed |
|---|---|
| Conditions: | Women's Studies |
| Therapuetic Areas: | Reproductive |
| Healthy: | No |
| Age Range: | Any |
| Updated: | 12/27/2017 |
| Start Date: | January 2008 |
| End Date: | June 2012 |
The purpose of this study is to test the feasibility of measuring body composition by air
displacement plethysmography (ADP) in rapidly growing, medically stable late gestation [32-35
weeks post-menstrual age (PMA)] premature infants.
displacement plethysmography (ADP) in rapidly growing, medically stable late gestation [32-35
weeks post-menstrual age (PMA)] premature infants.
1. To assess the feasibility of measuring body fat deposition by ADP in medically stable
late gestation (32-35 weeks), premature infants during a period of rapid postnatal
growth.
2. To test the relationship between %BF by ADP to %BF by DXA, as well as characterize the
relationship between these fat measures with bone measures by quantitative ultrasound
and serum levels of insulin, IGF-1, IGF binding proteins, adiponectin and leptin.
3. To perform inter- and intra-rater testing of anthropometric, ultrasound, and ADP
measurements.
4. Compare growth, body composition and bone strength between infants born preterm to
infants born full term.
late gestation (32-35 weeks), premature infants during a period of rapid postnatal
growth.
2. To test the relationship between %BF by ADP to %BF by DXA, as well as characterize the
relationship between these fat measures with bone measures by quantitative ultrasound
and serum levels of insulin, IGF-1, IGF binding proteins, adiponectin and leptin.
3. To perform inter- and intra-rater testing of anthropometric, ultrasound, and ADP
measurements.
4. Compare growth, body composition and bone strength between infants born preterm to
infants born full term.
Inclusion Criteria:
- Infants born between 32 4/7 and 35 3/7 weeks gestation or 37 4/7 and 42 3/7 weeks
gestation, by physical exam at birth
- Birth weight between the 5th and 95th percentile corrected for gestational age
Exclusion Criteria:
- Chromosomal abnormalities
- Major congenital anomalies
- Major surgery
- Severe CNS injury
- Inborn errors of metabolism
- Assisted ventilation
- Inability to start enteral feeds by 96 hours of age
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