Trial of an Intratumoral Injections of INXN-3001 in Subjects With Stage III or IV Melanoma



Status:Archived
Conditions:Skin Cancer
Therapuetic Areas:Oncology
Healthy:No
Age Range:Any
Updated:7/1/2011
Start Date:April 2009
End Date:December 2011

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Phase 1b' Open Label, Single Arm, Multicenter Trial to Evaluate the Safety, Tolerance, Response Rate and Immunological Effects of Repeated Intratumoral Injections of Adenoviral Transduced Autologous Dendritic Cells Engineered to Express hIL-12(INXN-3001) in Response to an Oral Activator Ligand Administered in Intra-Patient Escalating Doses in Patients With Unresectable Stage III C or IV Malignant Melanoma


The purpose of this study is to test the safety of an investigational combination
drug/immunotherapy for the treatment of Stage III/IV melanoma.


This study will examine the effects of an oral Activator Ligand administration to modulate
the timing of gene expression of human IL-12 by adenovirus-transduced dendritic cells
injected into tumors.


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Pittsburgh, PA
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801 North 29th Street
Billings, Montana 59107
406-238-2500
Billings Clinic Based in Billings, Montana, Billings Clinic is a community-governed health care organization consisting...
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Billings, MT
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Dallas, TX
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Goshen, IN
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Newark, Delaware 19713
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Newark, DE
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Orange, California 92868
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Orange, CA
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Park Ridge, Illinois 60068
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Park Ridge, IL
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Santa Monica, California 90404
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Santa Monica, CA
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Scottsdale, Arizona 85258
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Scottsdale, AZ
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