Trial Comparing Different Stimulation Paradigms in Patients Treated With Vagus Nerve Stimulation for Refractory Epilepsy



Status:Completed
Conditions:Neurology, Epilepsy
Therapuetic Areas:Neurology, Other
Healthy:No
Age Range:16 - Any
Updated:4/2/2016
Start Date:October 2005
End Date:December 2015
Contact:Veerle De Herdt, MD
Email:Veerle.deherdt@ugent.be

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Trial Summary
Trial Overview
Inclusion Criteria

Prospective Randomized Trial Comparing Different Stimulation Paradigms in Patients Treated With Vagus Nerve Stimulation for Refractory Epilepsy

Patients with refractory epilepsy who are candidates for a treatment with vagus nerve
stimulation will be prospectively randomized into 3 arms with different vagus nerve
stimulation paradigms. Vagus nerve stimulation parameters are programmed and adjusted during
outpatient clinic visits, within the normal clinical practice.


Inclusion Criteria:

- 16 years or older

- At least 1 seizure/month with alteration of consciousness

- Documented seizure diary, at least 3 months prior to implantation (baseline)

- No change in anti-epileptic drugs 1 month before implantation

- At least one or more AEDs

Exclusion Criteria:

- Active cardiac, pulmonary or gastrointestinal disease

- Vagotomy

- Concomitant use of an investigational drug

- Unstable medical condition

- Unstable psychiatric condition
We found this trial at
1
site
Dartmouth Hitchcock Medical Center
1 Medical Center Dr
Lebanon, New Hampshire 03756
 (603) 650-5000
Dartmouth Hitchcock Medical Center Dartmouth-Hitchcock is a national leader in patient-centered health care and building...
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from
Lebanon, NH
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