A Randomized Trial Of PF-00299804 Taken Orally Versus Erlotinib Taken Orally For Treatment Of Advanced Non-Small Cell Lung Cancer That Has Progressed After One Or Two Prior Chemotherapy Regimen



Status:Completed
Conditions:Lung Cancer, Cancer
Therapuetic Areas:Oncology
Healthy:No
Age Range:18 - 99
Updated:4/21/2016
Start Date:November 2008
End Date:August 2014

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A Randomized Phase 2 Trial Of Pf-00299804 Versus Erlotinib For The Treatment Of Advanced Non-small Cell Lung Cancer After Failure Of At Least One Prior Chemotherapy Regimen

This study will compare PF-00299804 given orally on continuous schedule to the approved
drug, erlotinib, in patients whose non-small cell lung cancer has progressed after
chemotherapy; patients will be randomized to receive one of these drugs, and followed for
efficacy and tolerance of each.


Inclusion Criteria:

- advanced measurable Non-Small Cell Lung Cancer (NSCLC);

- progressed after 1-2 prior chemotherapy;

- Eastern Cooperative Oncology Group (ECOG) 0-2;

- tissue available for future KRAS/ EGFR testing

Exclusion Criteria:

- prior Epidermal Growth Factor Receptor (EGFR) targeted therapy;

- active or untreated Central Nervous System (CNS) metastases;
We found this trial at
23
sites
Decatur, Georgia 30033
1924
mi
from 91732
Decatur, GA
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1919
mi
from 91732
Atlanta, GA
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1365 Clifton Rd NE
Atlanta, Georgia 30322
(404) 778-1900
Winship Cancer Institute at Emory University Winship Cancer Institute of Emory University is Georgia
1922
mi
from 91732
Atlanta, GA
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Augusta, Georgia 30901
2059
mi
from 91732
Augusta, GA
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Bethesda, Maryland 20817
2277
mi
from 91732
Bethesda, MD
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Bridgeport, Connecticut 06610
2473
mi
from 91732
Bridgeport, CT
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Camperdown, New South Wales 2050
7516
mi
from 91732
Camperdown,
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Clarksburg, West Virginia 26301
2102
mi
from 91732
Clarksburg, WV
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1831 Fifth Avenue
Columbus, Georgia 31904
(706) 320-8700
John B. Amos Cancer Center The John B. Amos Cancer Center located in Columbus, Georgia,...
1902
mi
from 91732
Columbus, GA
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Gainesville, Georgia 30501
1945
mi
from 91732
Gainesville, GA
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Macon, Georgia 31201
1974
mi
from 91732
Macon, GA
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Marietta, Georgia 30060
1907
mi
from 91732
Marietta, GA
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100 N Humphreys Blvd
Memphis, Tennessee 38120
(901) 683-0055
The West Clinic, PC Hello and welcome to our office. Although it is our pleasure...
1597
mi
from 91732
Memphis, TN
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Minneapolis, Minnesota 55455
1511
mi
from 91732
Minneapolis, MN
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Montebello, California 90640
6
mi
from 91732
Montebello, CA
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Muscle Shoals, Alabama 35661
1725
mi
from 91732
Muscle Shoals, AL
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Norwalk, Connecticut 06856
2461
mi
from 91732
Norwalk, CT
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Post Falls, Idaho 83854
944
mi
from 91732
Post Falls, ID
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Post Falls, Idaho 83854
944
mi
from 91732
Post Falls, ID
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Rockville, Maryland 20850
2272
mi
from 91732
Rockville, MD
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Warner Robins, Georgia 31088
1978
mi
from 91732
Warner Robins, GA
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Waterbury, Connecticut 06708
2479
mi
from 91732
Waterbury, CT
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Zion, Illinois 60099
1725
mi
from 91732
Zion, IL
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