TRIAD - Treatment of Insomnia and Depression



Status:Recruiting
Conditions:Depression, Insomnia Sleep Studies
Therapuetic Areas:Psychiatry / Psychology
Healthy:No
Age Range:18 - 75
Updated:11/30/2013
Start Date:December 2008
Contact:Haddas A Elisha, BSc
Email:helisha@stanford.edu
Phone:(650) 723-2641

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Improving Depression Outcome by Adding Insomnia Therapy to Antidepressants


The aim of the proposed three-site study is to increase the rate of full remission from
major depressive disorder (MDD) at the end of 16 weeks of treatment for people who
experience both major depressive disorder and insomnia.


Participants with major depressive disorder and insomnia who meet all study criteria will
receive state-of-the-art antidepressant medications and one of two insomnia therapies. The
specific therapy for insomnia will be determined by chance (like a flip of a coin), with an
equal chance to receive either cognitive-behavioral therapy for insomnia or desensitization
psychotherapy for insomnia. The study physician will select an initial antidepressant
medication from a list of three possible medications . If that medication is not helpful,
another medication may be tried after 8 weeks or in the event of severe side effects.

Inclusion Criteria:

1. Meets criteria for Major Depressive Disorder

2. Between 18 and 75 years of age and adequately fluent in English

3. Meets criteria for an insomnia disorder

Exclusion Criteria:

1. Women who are currently pregnant, breast-feeding, or not using a reliable birth
control method.

2. People for whom the antidepressant medication(s) provided in the study is not
indicated

3. People who have had minimum adequate trials of (or have not been able to tolerate)
all three study medications.

4. People with uncontrolled medical conditions.

5. People with moderate or severe sleep disorders other than insomnia

6. Individuals on a fixed night shift or rotating work schedule that requires a night
shift.

7. Patients with a current principal diagnosis of a psychiatric disorder that
necessitates treatment that is not offered in the study.
We found this trial at
3
sites
4200 Fifth Ave
Pittsburgh, Pennsylvania 15260
(412) 624-4141
University of Pittsburgh The University of Pittsburgh is a state-related research university, founded as the...
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Pittsburgh, PA
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Durham, North Carolina 27710
(919) 684-8111
Duke University Younger than most other prestigious U.S. research universities, Duke University consistently ranks among...
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Durham, NC
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291 Campus Dr
Stanford, California 94305
(650) 725-3900
Stanford University School of Medicine Vast in both its physical scale and its impact on...
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Stanford, CA
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