Inflammation and Vascular Function in Atherosclerosis
| Status: | Completed |
|---|---|
| Conditions: | Peripheral Vascular Disease, Cardiology |
| Therapuetic Areas: | Cardiology / Vascular Diseases |
| Healthy: | No |
| Age Range: | 18 - Any |
| Updated: | 11/30/-0001 |
| Start Date: | August 2005 |
| End Date: | February 2011 |
| Contact: | Whitney Redline, BA |
| Email: | wredline@partners.org |
| Phone: | 617 732-6320 |
The purpose of this study is to determine whether reducing inflammation in blood vessels
with an aspirin-like drug called salsalate will improve blood vessel function.
To test the hypothesis that inhibition of I [kappa] B kinase [beta] (IĸKβ), an inflammatory
mediator, by high dose salsalate, will restore insulin-mediated endothelium-dependent
vasodilation in subjects with atherosclerosis.
Inclusion Criteria:
- Non-smoking adult subjects with known atherosclerosis
Exclusion Criteria:
- Uncontrolled hypertension (> 140/90 mmHg)
- Untreated hypercholesterolemia (LDL > 160 mg/dL)
- Diabetes mellitus
- ALT > 150
- Creatinine > 1.4 mg/dL
- Concommitant use of warfarin
We found this trial at
1
site
Brigham and Women's Hosp Boston’s Brigham and Women’s Hospital (BWH) is an international leader in...
Click here to add this to my saved trials
