Vitamin D Deficiency and Low Bone Mineral Content in Children



Status:Archived
Conditions:Obesity Weight Loss, Other Indications, Gastrointestinal
Therapuetic Areas:Endocrinology, Gastroenterology, Other
Healthy:No
Age Range:Any
Updated:7/1/2011
Start Date:July 2008
End Date:June 2011

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The Relationship Between Vitamin D Deficiency and Low Bone Mineral Content in Children


The Vitamin D study is designed to investigate the effect of body fat mass on vitamin D
levels in children. Earlier studies have shown that individuals with increased fat mass may
have low vitamin D levels.

Our specific hypothesis states that children with increased fat mass will have lower blood
levels of vitamin D when compared to non-obese children.Since vitamin D is the primary
hormone for bone mineralization in humans, low levels of vitamin D could lead to decreased
bone mineral content in these children.


Fifty prepubertal male and female children of ages between 3-12 years will participate in
this study. Of these, 25 obese children will be enrolled in the study group, and 25
non-obese children will serve as controls.

All subjects will fill out a comprehensive mineral intake questionnaire as part of the study
to ensure adequate calcium intake prior to the study.

All subjects will collect a first morning urine sample for calcium, creatinine, and NTX.

Fasting blood samples will be drawn for the following analytes: 25-hydroxyvitamin D, 1,
25-dihydroxyvitamin D, intact PTH, calcium, phosphorus, magnesium, osteocalcin, insulin,
c-peptide, fasting blood glucose, leptin, and adiponectin.

Bone Mineral Content will be evaluated in 16 obese subjects with vitamin D level of < 30
nmol/L.


We found this trial at
1
site
55 Lake Avenue North
Worcester, Massachusetts 01655
508-334-1000
Umass Memorial Medical Center UMass Memorial Medical Center is the region's trusted academic medical center,...
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Worcester, MA
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