Total Knee Arthroplasty And Thromboembolism: A Comparison Between Two Surgical Techniques



Status:Archived
Conditions:Cardiology, Orthopedic
Therapuetic Areas:Cardiology / Vascular Diseases, Orthopedics / Podiatry
Healthy:No
Age Range:Any
Updated:7/1/2011
Start Date:June 2006
End Date:June 2009

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In patients undergoing total knee arthroplasty, thromboembolism is a common occurrence,
especially following tourniquet deflation. The resulting cardiopulmonary emboli can
potentially lead to hypoxemia, hypotension, hemodynamic collapse and post operative
cognitive dysfunction due to emboli. The standard surgical technique involves placing an
intramedullary rod in the femur to determine the angle and degree of resection from the end
of the femur. A new surgical technique utilizes computer navigation system to perform the
desired cuts in the appropriate position. The investigators hypothesize that the avoidance
of intramedullary instrumentation in computer assisted total knee replacement will result in
fewer thromboembolic events compared with the standard technique using manual
instrumentation in the femur. The present study will test this hypothesis by quantifying
the extent of thromboembolism during both surgical techniques.


Currently, Transesophageal Echocardiography (TEE) is routinely used intraoperatively to
monitor patients undergoing total knee arthroplasty for thromboembolic events. Video
recording (without any patient identifiers) of the TEE loops before and after tourniquet
release, offline analysis to quantify the extent of thromboembolism and the two surgical
techniques will be compared. Patients are assigned to a particular technique according to
some non-rigid criteria. This study has no impact on their selection into one group or the
other. Participation in this study does not influence the choice/selection. We will simply
record and analyze the echo loops in twenty patients already assigned to each surgical
technique.


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