Treatment Based on Molecular Profiling Diagnosis Carcinoma of Unknown Primary Site



Status:Archived
Conditions:Cancer
Therapuetic Areas:Oncology
Healthy:No
Age Range:Any
Updated:7/1/2011
Start Date:August 2008
End Date:August 2011

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A Phase II Study of Chemotherapy Treatment Based on Molecular Profiling Diagnosis for Patients With Carcinoma of Unknown Primary Site


This is a non-randomized Phase II study. Patients determined at initial diagnosis to have a
carcinoma of unknown primary site will have their treatment selected with the use of a
molecular profiling assay. A molecular profiling assay will be performed on
paraffin-embedded tumor tissue from a biopsy specimen. Patients given specific diagnoses
(e.g., lung, pancreas, colon, breast, renal cell, prostate and ovarian cancer) will receive
treatment regimens of proven activity. If no specific diagnosis is made with the molecular
profiling assay, empiric chemotherapy with paclitaxel, carboplatin, bevacizumab and
erlotinib will be administered.


Patients in all subgroups will be evaluated for response to treatment after completing 2
cycles. Standard, disease specific, restaging methods will be employed. Patients with
objective response or stable disease will continue treatment, with subsequent re-evaluations
after every 2 cycles of therapy.


We found this trial at
20
sites
Gainesville, Florida 30501
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Gainesville, FL
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3840 Broadway
Fort Myers, Florida 33901
(239) 275-6400
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Fort Myers, FL
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9143 Philips Hwy # 560
Jacksonville Beach, Florida 32250
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Jacksonville Beach, FL
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1730
Lakeland, Florida 33805
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Lakeland, FL
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2501 N Orange Ave # 235
Orlando, Florida 32804
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Orlando, FL
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Baton Rouge, Louisiana 70806
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Baton Rouge, LA
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6410 Rockledge Dr #660
Bethesda, Maryland 20817
(301) 571-0019
Center for Cancer & Blood Disorders Widely recognized for its compassionate, expert care, the Center...
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Bethesda, MD
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Chattanooga, Tennessee 37404
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Chattanooga, TN
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5053 Wooster Rd
Cincinnati, Ohio 45226
(513) 751-2273
Oncology Hematology Care Our more than 60 physicians and advanced practice providers throughout neighborhood offices...
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Cincinnati, OH
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Evansville, IN
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Grand Rapids, Michigan 49503
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Grand Rapids, MI
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Huntsville, Alabama 35805
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Huntsville, AL
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Jackson, Mississippi 39202
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Jackson, MS
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Louisville, Kentucky 40207
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Louisville, KY
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Marietta, Georgia 30060
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Marietta, GA
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Morristown, New Jersey 07960
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Morristown, NJ
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250 25th Ave N, Ste 100
Nashville, Tennessee 37023
615-320-5090
Tennessee Oncology, PLLC Since 1976 Tennessee Oncology has been providing quality cancer care. In 2013,...
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Nashville, TN
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8303 Dodge Street
Omaha, Nebraska 68114
(402) 354–4000
Nebraska Methodist Hospital Methodist Hospital is a general medical and surgical hospital in Omaha, NE....
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Omaha, NE
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Richmond, Virginia 23235
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Richmond, VA
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Spartanburg, South Carolina 29303
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Spartanburg, SC
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