Effectiveness of a Family-Based Intervention for Adolescent Suicide Attempters (The SAFETY Study)

Suicide is consistently a leading cause of death among adolescents in the United States,
making suicide prevention a serious public health concern. The risk factors for suicide vary
but are often related to depression and other mental disorders, substance abuse, a major
stressful event, and family history of suicide. Despite the morbidity and mortality
associated with suicide attempts in adolescents, there is a lack of empirically supported
treatment strategies and consensus regarding the best practices for suicide prevention. The
SAFETY intervention is an individually tailored treatment strategy that integrates family-
and community-based interventions and cognitive behavioral therapy and links youth to needed
services and resources. SAFETY may be an effective means of reducing suicide attempts and
improving mental health in at-risk adolescents. This study will evaluate the effectiveness
of SAFETY in reducing suicide and suicide attempts in adolescents.

This study will be divided into two phases. Participants in Phase I will all receive 12
weeks of the family-based cognitive behavioral therapy intervention SAFETY. Phase I will be
used to develop the intervention manual, protocols, and adherence measures for SAFETY in
Phase II. Phase I participants will undergo assessments at baseline and Week 12. Assessments
will last 90 minutes and will include a series of interviews and questionnaires concerning
family, general health, and mental health-related issues.

Participants in Phase II will be assigned randomly to receive 12 weeks of SAFETY or enhanced
usual care. The frequency of sessions, which will involve both youth and parent
participants, will vary on the basis of the individual needs of participants. SAFETY
sessions will be individually tailored for each participant's specific needs and will
include the following elements: (1) family- and community-based interventions aimed at
mobilizing family and community networks that support youth safety, adaptive behavior, and
reasons for living; (2) cognitive behavioral treatment modules that focus on decreasing
suicidality and preventing repeat suicide attempts; and (3) an individualized care linkage
strategy that links youth to needed services and resources. At baseline, Week 12, and Month
6, all youth and parent participants will undergo the same assessments that were performed
during Phase I.

Inclusion Criteria:

- Suicide attempt in the 3 months before study entry

Exclusion Criteria:

- Psychosis

- Substance dependency

- Immediate risk of out-of-home placement

- Symptoms/conditions that would interfere with assessment and/or intervention
protocols