The Effect of Beta-glucan in Non-Small Cell Lung Cancer

Beta-glucan (Imucell WGP) is an over-the-counter dietary supplement that enhances the body's
immune system. Imucell WGP is extracted from food-grade baker's yeast, which is permitted for
use in food by the U.S. Food and Drug Administration (FDA). Studies in animals have shown
that Imucell WGP helps trigger white blood cells to destroy cancer cells. Other animal
studies combining Imucell WGP with anti-cancer medications have shown greater tumor
regression and tumor-free survival.

AIM 2:

Inclusion Criteria:

- suspected or definitive diagnosis of non-small cell lung cancer (NSCLC)

- treatment naive or no treatment within 6 months prior to enrollment

- able to swallow pills

- Eastern Cooperative Oncology Group (ECOG) performance status of 0 to 3

- absolute neutrophil count (ANC) at least 1500/microl

- able to understand and willing to sign a written informed consent document

Exclusion Criteria:

- history of hypersensitivity reactions attributed to beta-glucan

- currently receiving continuous corticosteroids or other ongoing immunosuppressive
therapy

- presence of an uncontrolled intercurrent illness including but not limited to: ongoing
or active infection, symptomatic congestive heart failure, unstable angina pectoris,
cardiac arrhythmia, or psychiatric illness/social situations that would limit
compliance with study requirements

AIM 3:

Inclusion Criteria:

- resectable non-small cell lung cancer (NSCLC), as determined by a thoracic surgeon

- treatment naive

- able to swallow pills

- Eastern Cooperative Oncology Group (ECOG) performance status of 0 to 2

- must be an operative candidate

- absolute neutrophil count (ANC) at least 1500/microl

- able to understand and willing to sign a written informed consent document

Exclusion Criteria:

- history of hypersensitivity reactions attributed to beta-glucan

- currently receiving continuous corticosteroids or other ongoing immunosuppressive
therapy

- presence of an uncontrolled intercurrent illness including but not limited to: ongoing
or active infection, symptomatic congestive heart failure, unstable angina pectoris,
cardiac arrhythmia, or psychiatric illness/social situations that would limit
compliance with study requirements