Sorafenib Tosylate and Erlotinib Hydrochloride in Treating Patients With Locally Advanced, Unresectable, or Metastatic Gallbladder Cancer or Cholangiocarcinoma
| Status: | Archived |
|---|---|
| Conditions: | Liver Cancer, Cancer, Cancer |
| Therapuetic Areas: | Oncology |
| Healthy: | No |
| Age Range: | Any |
| Updated: | 7/1/2011 |
| Start Date: | May 2010 |
Phase II Study of Sorafenib (NSC-724772) and Erlotinib (NSC-718781) in Patients With Advanced Gallbladder Carcinoma or Cholangiocarcinoma
RATIONALE: Sorafenib tosylate and erlotinib hydrochloride may stop the growth of tumor cells
by blocking some of the enzymes needed for cell growth or by blocking blood flow to the
tumor.
PURPOSE: This phase II trial is studying how well giving sorafenib tosylate together with
erlotinib hydrochloride works in treating patients with locally advanced, unresectable, or
metastatic gallbladder cancer or cholangiocarcinoma.
OBJECTIVES:
- To assess the progression-free survival of patients with unresectable or metastatic
gallbladder carcinoma or cholangiocarcinoma treated with the combination of sorafenib
tosylate and erlotinib hydrochloride.
- To assess the overall survival of patients treated with this regimen.
- To assess the objective response rate in patients treated with this regimen.
- To assess the frequency and severity of toxicities of this regimen in these patients.
- To collect specimens for banking for future research.
OUTLINE: This is a multicenter study.
Patients receive oral sorafenib tosylate twice daily and oral erlotinib hydrochloride once
daily on days 1-28. Treatment repeats every 28 days in the absence of disease progression or
unacceptable toxicity.
After completion of study therapy, patients are followed up every 6 months for 3 years.
We found this trial at
150
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Adena Regional Medical Center Since 1895, Adena Health System has remained focused on its commitment...
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Doctors Hospital Nationally recognized for care quality and patient safety and satisfaction, Doctors Hospital is...
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Mount Carmel Health - West Hospital Located near downtown Columbus, Mount Carmel West is the...
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Danville Regional Medical Center For more than 120 years, Danville Regional Medical Center has been...
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Dayton CCOP We are a regional non-profit cancer research consortium serving the Miami Valley area...
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Good Samaritan Hospital - Dayton Good Samaritan Hospital (GSH) is passionate about providing the most...
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18101 Oakwood Blvd
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Oakwood Cancer Center at Oakwood Hospital and Medical Center In today's health care environment, a...
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Decatur Memorial Hospital Cancer Care Institute An American flag bearing only 48 stars waved above...
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Cancer Center of Kansas, PA - Dodge City Dr. H.E. Hynes founded Cancer Center of...
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Blanchard Valley Medical Associates Blanchard Valley Medical Associates was founded in 1974 by Dr. William...
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Sletten Cancer Institute at Benefis Healthcare Benefis Hospitals has 516 beds at its two campuses...
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Foote Memorial Hospital Allegiance Health is a community-owned, locally-governed health system in Jackson, Michigan. We...
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Kalispell Regional Medical Center Nestled in the beautiful Flathead Valley of Northwestern Montana, Kalispell Regional...
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Knox Community Hospital A community-owned, 115-bed, not-for-profit hospital located in Mount Vernon, Ohio (approximately 40...
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