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New Clinical Trials for Depression

Depression clinical research has lead to many advances in its treatment and management over the last several decades. However, it is not a condition that is completely understood. The treatments for depression also need more research. While many antidepressants help most patients some of them actually make the symptoms worse in a small group of patients.
 
It is obvious that there is still a lot to learn from further depression clinical studies. There are ongoing depression clinical trials that could benefit from your participation if you suffer from depression. If you think you may qualify please review the list of current trials. Participation is always at no cost to you.
 

What is Depression?

Depression is described as a state of mind focused on sadness, hopelessness, feelings of worthlessness, and a loss of pleasure or concern with every day activities. Depressed people often have trouble sleeping or they sleep too much. They feel tired, drained of all energy or enthusiasm and often contemplate suicide. Depression can range from a few weeks of mild depression to a chronic lifelong series of major depressive episodes. Depression is also known as major depressive disorder (MDD), mood disorder and clinical depression. Depression is believed to be caused by changes in the neurotransmitters in the brain such as serotonin.
 

Depression Treatments

Treating depression is usually done with a combination of antidepressants and psychotherapy. Today’s antidepressant medications are relatively safe with few side effects. While they have been shown less effective in mild cases of depression, they are very effective in more serious cases of depression. Treating depression in severe cases where the patient may want to harm himself or herself or someone else sometimes leads to a period of hospitalization. Less frequently electroconvulsive therapy is used to treat depression. This involves shock therapy to the brain and is a controversial treatment.

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Showing 1-100 of 1338
There are 1338 Depression Clinical Trials
Name City State Zip
Depression Clinical Trial DeLand FL 32720
Safety and Efficacy of F2695 SR in Major Depressive Disorder Dothan AL 36305
A Study to Evaluate the Efficacy and Safety of Armodafinil Treatment as Adjunctive Therapy in Adults With Major Depression Associated With Bipolar I Disorder Birmingham, AL 35216
Study of the Safety and Efficacy of OPC-34712 as Adjunctive Therapy in the Treatment of Adults With Major Depressive Disorder Birmingham AL 35233
Efficacy, Safety and Tolerability of Agomelatine Sublingual Tablets in the Treatment of Major Depressive Disorder Birmingham AL 25226
Efficacy, Safety and Tolerability of Agomelatine Sublingual Tablets in the Treatment of Major Depressive Disorder (MDD) Birmingham AL 35294
Study to Evaluate the Efficacy, Safety and Tolerability of an Oral Aripiprazole/Escitalopram Combination Therapy in Patients With Major Depressive Disorder (MDD) Birmingham AL
Extension Study of the Safety and Efficacy of Armodafinil Treatment as Adjunctive Therapy in Adults With Major Depression Associated With Bipolar I Disorder Birmingham AL 35226
Paliperidone and Lithium in the Treatment of Suicidality - Treatment Indication and Epigenetic Regulation Birmingham AL 35233
A Study to Assess the Efficacy and Safety of TC-5214 as an Adjunct Therapy in Patients With Major Depressive Disorder Birmingham AL
Open-label Long Term (52 Weeks) Safety and Tolerability of Agomelatine Sublingual Tablets in Major Depressive Disorder (MDD) Birmingham AL 35233
A Study to Assess the Efficacy and Safety of TC-5214 as an Adjunct Therapy in Patients With Major Depressive Disorder (MDD) Birmingham AL
Safety and Efficacy of F2695 SR in Adults With Fatigue Associated With Major Depressive Disorder Birmingham AL 35216
A Trial of Group Psychotherapy for Veterans and Military Personnel With Post Traumatic Stress Disorder (PTSD) Tucson AZ 85721
A Trial of Group Psychotherapy for Veterans and Military Personnel With Post Traumatic Stress Disorder (PTSD) Tucson AZ 85723
Multifamily Psychoeducation and Cognitive Remediation for Recent-Onset Psychosis Tucson AZ 85721
Efficacy, Safety and Tolerability of CX157 in Treatment Resistant Depression Tucson AZ 85724
Morbidity and Mortality Among Dialysis Patients After Treatment for Depression Phoenix AZ 85012
Open-label Long Term (52 Weeks) Safety and Tolerability of Agomelatine Sublingual Tablets in Major Depressive Disorder (MDD) Phoenix AZ 85254
A Study to Assess the Efficacy and Safety of TC-5214 as an Adjunct Therapy in Patients With Major Depressive Disorder (MDD) Phoenix AZ
Study to Evaluate the Efficacy, Safety and Tolerability of an Oral Aripiprazole/Escitalopram Combination Therapy in Patients With Major Depressive Disorder (MDD) Peoria AZ
Open-label Long Term (52 Weeks) Safety and Tolerability of Agomelatine Sublingual Tablets in Major Depressive Disorder (MDD) Glendale AZ 85308
Cradling Our Future Through Family Strengthening Study Fort Defiance AZ 86540
Hepatitis C Translating Initiatives for Depression Into Solutions No. Little Rock AR 72114
Efficacy and Safety of Flexibly Dosed BMS-820836 in the Treatment of Patients With Treatment Resistant Major Depression Little Rock AR 72201
Study to Evaluate the Efficacy, Safety and Tolerability of an Oral Aripiprazole/Escitalopram Combination Therapy in Patients With Major Depressive Disorder (MDD) Little Rock AR
A Study to Assess the Efficacy and Safety of TC-5214 as an Adjunct Therapy in Patients With Major Depressive Disorder Little Rock AR
Open-label Long Term (52 Weeks) Safety and Tolerability of Agomelatine Sublingual Tablets in Major Depressive Disorder (MDD) Little Rock AR 72205
A Study to Assess the Efficacy and Safety of TC-5214 as an Adjunct Therapy in Patients With Major Depressive Disorder (MDD) Little Rock AR
Efficacy and Safety of Lu AA21004 in Adults With Major Depressive Disorder Little Rock AR
Safety and Efficacy of F2695 SR in Adults With Fatigue Associated With Major Depressive Disorder Little Rock AR 72223
A Study Of The Efficacy And Safety Of CP-601,927 Augmentation Of Antidepressant Therapy In Major Depression Fayetteville AR 72703
A Safety Study in Patients With Major Depressive Disorder Fayetteville AR 72703
Family Cognitive Behavioral Therapy for Preventing Depression in Children Ventura CA 93003
Open-label Long Term (52 Weeks) Safety and Tolerability of Agomelatine Sublingual Tablets in Major Depressive Disorder (MDD) Torrance CA 90502
A Study to Evaluate the Efficacy and Safety of Armodafinil Treatment as Adjunctive Therapy in Adults With Major Depression Associated With Bipolar I Disorder Temecula CA 92591
Efficacy, Safety and Tolerability of Agomelatine Sublingual Tablets in the Treatment of Major Depressive Disorder (MDD) Temecula CA 92591
Extension Study of the Safety and Efficacy of Armodafinil Treatment as Adjunctive Therapy in Adults With Major Depression Associated With Bipolar I Disorder Temecula CA 92591
Open-label Long Term (52 Weeks) Safety and Tolerability of Agomelatine Sublingual Tablets in Major Depressive Disorder (MDD) Temecula CA 92591
TRIAD - Treatment of Insomnia and Depression Stanford CA 94305
Treatment Trial for Psychogenic Nonepileptic Seizures Stanford CA 94305
Lurasidone - A 6-week Study of Patients With Bipolar I Depression (Add-on) Stanford CA 94305
Lurasidone - A 24-week Extension Study of Patients With Bipolar I Depression Stanford CA 94305
Functional MRI Before and After Treatment for Depression Stanford CA 94305
Imaging the Nucleus Accumbens in Major Depressed Patients Treated With Pramipexole Stanford CA 94305
Insulin Resistance in Patients With Major Depression Stanford CA 94305
Mothers With a History of Depression and Their 10-14 Year Old Daughters Stanford CA 94305
Mothers With a History of Depression and Their 10-14 Year Old Daughters Stanford CA 94305
Relapse-Prevention Study With F2695 SR in Patients With Major Depressive Disorder Sherman Oaks CA 91403
Anxiety and Depression Levels in Cancer Patients After Self-Application of EFT (Emotional Freedom Techniques) Santa Rosa CA 95403
A Study of RO4917523 in Patients With Treatment Resistant Depression Santa Clara CA 95051
Study to Evaluate the Efficacy, Safety and Tolerability of an Oral Aripiprazole/Escitalopram Combination Therapy in Patients With Major Depressive Disorder (MDD) Santa Clara CA 95051
Study to Evaluate the Efficacy, Safety and Tolerability of an Oral Aripiprazole/Escitalopram Combination Therapy in Patients With Major Depressive Disorder (MDD) Santa Clara CA 95051
Study to Evaluate the Efficacy, Safety and Tolerability of an Oral Aripiprazole/Escitalopram Combination Therapy in Patients With Major Depressive Disorder (MDD) Santa Clara CA 95051
A Safety and Efficacy Study of 26489112 in Patients With Treatment-Resistant Major Depressive Disorder Santa Clara CA 95051
Safety and Efficacy of Lu AA21004 in Adults With Major Depressive Disorder Santa Clara CA 95051
Efficacy and Safety Study of Lu AA21004 in Adults With Major Depressive Disorder Santa Clara CA 95051
Efficacy and Safety of Lu AA21004 in Adults With Major Depressive Disorder Santa Clara CA 95051
A Paroxetine- and Placebo-Controlled Study of 50 mg/Day and 100 mg/Day of EB-1010 Among Outpatients With Major Depressive Disorder Who Have Responded Inadequately to Prior Selective Serotonin Reuptake Inhibitors (SSRIs) and Serotonin Norepinephrine Reuptake Inhibitors (SNRIs) Santa Ana CA 92705
Study of the Safety and Efficacy of OPC-34712 as Adjunctive Therapy in the Treatment of Adults With Major Depressive Disorder Santa Ana CA 92701
A Study to Evaluate the Efficacy and Safety of Armodafinil Treatment as Adjunctive Therapy in Adults With Major Depression Associated With Bipolar I Disorder Santa Ana CA 92705
Safety and Efficacy of EVT 101 in Treatment-Resistant Depression Santa Ana CA
Open-label Long Term (52 Weeks) Safety and Tolerability of Agomelatine Sublingual Tablets in Major Depressive Disorder (MDD) Santa Ana CA 92701
Antidepressant Medication Plus Directly Observed Therapy for Improving Adherence to Antiretroviral Therapy San Francisco CA 94102
Motivational Interviewing to Engage Operations Enduring Freedom and Iraqi Freedom (OEF/OIF) Veterans in Mental Health Treatment San Francisco CA 94121
Effectiveness of a Web-based Prevention Program for Postpartum Depression San Francisco CA 94115
Practicing Alternative Techniques to Heal From Depression: The PATH-D Study San Francisco CA 94115
Practicing Alternative Techniques to Heal From Depression: The PATH-D Study San Francisco CA 94143
Activating Messages for Enhancing Primary Care Practice (AMEP2): Effectiveness Study San Francisco CA 94115
Depression Management Project San Francisco CA 94115
Open-label Long Term (52 Weeks) Safety and Tolerability of Agomelatine Sublingual Tablets in Major Depressive Disorder (MDD) San Francisco CA 94115
Study of the Safety and Efficacy of OPC-34712 as Adjunctive Therapy in the Treatment of Adults With Major Depressive Disorder San Fernando Valley CA 91403
Safety and Efficacy of 12 Weeks of Varenicline for Smoking Cessation in Smokers With Depression San Fernando Valley CA 91403
Efficacy, Safety and Tolerability of Agomelatine Sublingual Tablets in the Treatment of Major Depressive Disorder (MDD) San Fernando Valley CA 91403
Teen Depression Awareness Project (TDAP) San Fernando CA 91340
Lurasidone - A 6-week Study of Patients With Bipolar I Depression (Add-on) San Diego CA 92102
Lurasidone - A 6-week Study of Patients With Bipolar I Depression (Monotherapy) San Diego CA 92102
Lurasidone - A 24-week Extension Study of Patients With Bipolar I Depression San Diego CA 92102
Using Cognitive Training to Improve Employment Programs for People With Severe Mental Illnesses San Diego CA 92103
A Study to Assess the Safety and Effect of TC-5214 in Patients With Major Depressive Disorder. San Diego CA
Intervention for Veterans With Depression, Substance Disorder, and Trauma San Diego CA 92161
Study of the Safety and Efficacy of OPC-34712 as Adjunctive Therapy in the Treatment of Adults With Major Depressive Disorder San Diego CA 92108
A Study to Evaluate the Efficacy and Safety of Armodafinil Treatment as Adjunctive Therapy in Adults With Major Depression Associated With Bipolar I Disorder San Diego CA 92123
Relapse-Prevention Study With F2695 SR in Patients With Major Depressive Disorder San Diego CA 92108
Efficacy, Safety and Tolerability of Agomelatine Sublingual Tablets in the Treatment of Major Depressive Disorder San Diego CA 92103
Efficacy, Safety and Tolerability of Agomelatine Sublingual Tablets in the Treatment of Major Depressive Disorder San Diego CA 92102
Efficacy, Safety and Tolerability of Agomelatine Sublingual Tablets in the Treatment of Major Depressive Disorder (MDD) San Diego CA 92108
Extension Study of the Safety and Efficacy of Armodafinil Treatment as Adjunctive Therapy in Adults With Major Depression Associated With Bipolar I Disorder San Diego CA 92123
Safety and Efficacy of EVT 101 in Treatment-Resistant Depression San Diego CA
Brief Cognitive Behavioral Therapy (CBT) for Pediatric Anxiety and Depression in Primary Care San Diego CA 92120
A Study to Assess the Efficacy and Safety of TC-5214 as an Adjunct Therapy in Patients With Major Depressive Disorder San Diego CA
Open-label Long Term (52 Weeks) Safety and Tolerability of Agomelatine Sublingual Tablets in Major Depressive Disorder (MDD) San Diego CA 92102
A Study to Assess the Efficacy and Safety of TC-5214 as an Adjunct Therapy in Patients With Major Depressive Disorder (MDD) San Diego CA
Telemedicine for Improved Delivery of Psychosocial Treatments for Post Traumatic Stress Disorder San Diego CA 92161
Acceptance and Commitment Therapy (ACT) for OEF/OIF Veterans San Diego CA 92161
Efficacy, Safety and Tolerability of Agomelatine Sublingual Tablets in the Treatment of Major Depressive Disorder (MDD) San Bernardino CA 92374
Safety and Efficacy of F2695 SR in Major Depressive Disorder Sacramento CA 95817
Safety and Efficacy of F2695 SR in Adults With Fatigue Associated With Major Depressive Disorder Riverside CA 92506
Lurasidone - A 6-week Study of Patients With Bipolar I Depression (Add-on) Pico Rivera CA 90660
Lurasidone - A 6-week Study of Patients With Bipolar I Depression (Monotherapy) Pico Rivera CA 90660

Showing 1-100 of 1338
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