Melphalan and Dexamethasone With or Without Bortezomib in Treating Patients With Previously Untreated Systemic Light-Chain Amyloidosis
Status: | |
---|---|
Conditions: | Cancer, Blood Cancer, Hematology |
Therapuetic Areas: | Hematology, Oncology |
Healthy: | No |
Age Range: | Any |
Updated: | 8/15/2012 |
Start Date: | November 2010 |
A Randomized Phase III Trial of Melphalan and Dexamethasone (MDex) Versus Bortezomib, Melphalan and Dexamethasone (BMDex) for Untreated Patients With Systemic Light-Chain (AL) Amyloidosis Ineligible for Autologous Stem-Cell Transplantation
RATIONALE: Drugs used in chemotherapy, such as melphalan and dexamethasone, work in
different ways to stop the growth of plasma cells, either by killing the cells or by
stopping them from dividing. Bortezomib may stop the growth of plasma cells by blocking some
of the enzymes needed for cell growth. It is not yet known whether giving melphalan together
with dexamethasone is more effective with or without bortezomib in treating systemic
amyloidosis.
PURPOSE: This randomized phase III trial is studying melphalan and dexamethasone to see how
well they work with or without bortezomib in treating patients with previously untreated
systemic amyloidosis.
OBJECTIVES:
Primary
- To compare hematologic overall response (partial response [PR], very good PR, amyloid
complete hematologic response [ACR], and stringent complete response [sCR]) after 3
courses of therapy in patients with previously untreated systemic light-chain
amyloidosis treated with melphalan and dexamethasone with vs without bortezomib.
Secondary
- To evaluate the ACR rate after 3 courses of therapy and at completion of therapy.
- To evaluate organ response rates after 3 courses of therapy and at 6, 9, and 12 months.
- To evaluate treatment-related mortality.
- To evaluate toxicity.
- To evaluate progression-free and overall survival.
- To evaluate PR or better at completion of therapy.
- To evaluate time to hematologic and organ response.
- To evaluate the duration of hematologic and organ response.
- To assess QOL at baseline, at 3, 6, and 9 months during the therapy, at completion of
therapy, and 3 and 6 months after therapy.
Tertiary
- To determine the prognostic impact of t(11;14) translocation and cyclin D1
overexpression on response and overall survival. (Correlative)
- To compare sCR rates and to determine the impact of sCR on the outcomes. (Correlative)
- To perform a descriptive analysis of amyloid typing and proteomic composition of
amyloid tissues. (Correlative)
OUTLINE: This is a multicenter study. Patients are stratified according to amyloid cardiac
stage (I or II vs better-risk III) and are randomized to 1 of 2 treatment arms.
- Arm I: Patients receive oral melphalan and oral dexamethasone on days 1-4. Treatment
repeats every 28 days for up to 9 courses in the absence of disease progression or
unacceptable toxicity.
- Arm II: Patients receive oral melphalan and oral dexamethasone on days 1-4 and
bortezomib IV or subcutaneously (SC) on days 1, 4, 8, and 11. Treatment repeats every
28 days for 2 courses. Patients then receive oral melphalan and oral dexamethasone on
days 1-4 and bortezomib IV or SC on days 1, 8, 15, and 22. Treatment repeats every 35
days for up to 6 courses in the absence of disease progression or unacceptable
toxicity.
Blood, urine, bone marrow, and fat samples may be collected periodically for laboratory
analysis.
Health-related quality of life is assessed periodically before, during, and after therapy.
After completion of study treatment, patients are followed up every 3-6 months for 5 years.
DISEASE CHARACTERISTICS:
- Histologically confirmed diagnosis of systemic light-chain amyloidosis
- Histologic diagnosis of disease must be confirmed by pathology (positive Congo
red stain with green birefringence on polarized light microscopy)
- Genetic testing must be negative for transthyretin mutations associated with
hereditary amyloidosis (required in patients who are African-American or who present
with peripheral neuropathy as the dominant organ involvement)
- Measurable disease, defined by ≥ 1 of the following:
- Serum M-protein ≥ 1 g/dL
- Difference between involved and uninvolved free light chain be > 4.0 mg/dL
provided the kappa to lambda free light chain ratio is abnormal
- Symptomatic organ involvement* (heart, kidney, liver/gastrointestinal tract,
peripheral nervous system, or soft tissue), defined as any of the following:
- Renal involvement is defined as proteinuria (predominantly albumin) > 0.5 g/day
by 24-hour urine collection
- Cardiac involvement is defined as the presence of a mean left ventricular wall
thickness of > 12 mm by ECHO in the absence of a history of hypertension or
valvular heart disease or in the presence of unexplained low voltage (< 0.5 mV)
by ECG
- Hepatic involvement is defined as hepatomegaly or an alkaline phosphatase > 1.5
times upper limit of normal (ULN)
- Peripheral nerve involvement is defined by clinical history or abnormal sensory
and/or motor findings on neurologic exam
- Gastrointestinal (GI) involvement is defined as gross GI bleeding or diarrhea
(at least 4 stools per day over baseline); a positive GI biopsy is not
sufficient to document clinical involvement
- Autonomic nerve involvement is defined as orthostasis, symptoms of nausea or
dysgeusia, gastric atony by gastric emptying scan, diarrhea, or constipation
- Soft tissue and lymphatic involvement may be ascertained based on classic
physical exam findings (macroglossia, shoulder pad sign, raccoon eyes, carpal
tunnel syndrome, synovial enlargement, firm enlarged lymph nodes) or biopsy
- NOTE: *Carpal tunnel syndrome skin purpura or the presence of vascular amyloid on a
bone marrow biopsy alone are not sufficient to meet criteria for "symptomatic organ
involvement"
- Amyloid cardiac biomarker stage I, II, or better-risk stage III disease
- Staging defined by NT-proBNP and troponin T cut-offs of < 332 pg/mL and < 0.035
ng/mL, respectively, as thresholds: stage I, both under threshold; stage II,
either troponin or NT-proBNP (but not both) over threshold (if troponin T is not
available at local institution, troponin I may be used, but the threshold must
be < 0.1 ng/mL); stage III, troponin-T (or I) and simultaneous NT-proBNP above
the threshold
- Stage III patients are further classified as "better-risk" if NT-proBNP is
over 332 ng/L but less than 6,000 ng/L
- No clinically overt myeloma (hypercalcemia or lytic bone lesions)
- Ineligible for autologous stem cell transplantation with melphalan 200 mg/m^2 or
refuses to undergo transplantation
PATIENT CHARACTERISTICS:
- ECOG performance status 0-2
- ANC > 1,500/mm^3
- Platelet count > 140,000/mm^3
- Hemoglobin > 10 g/dL
- Total bilirubin < 2.5 mg/dL
- Alkaline phosphatase < 5 times ULN
- AST < 3 times ULN
- Creatinine clearance > 30 mL/min
- Bone marrow plasma cells < 30%
- Not pregnant or nursing
- Negative pregnancy test
- Fertile patients must use effective contraception
- No history of sustained ventricular tachycardias
- The absence of supine systolic blood pressure < 100 mm Hg and difficult to manage
symptomatic orthostatic hypotension
- No symptomatic orthostatic hypotension that is difficult to manage
- No cardiac syncope
- No uncompensated NYHA class III or IV congestive heart failure
- No uncontrolled infection
- No active malignancy within the past 5 years except for adequately treated basal cell
or squamous cell skin cancer, in situ cervical cancer, or adequately treated stage I
cancer currently in complete remission
- No serious medical or psychiatric illness likely to interfere with study
participation, including recent myocardial infarction (within the past 6 months) or
poorly controlled diabetes mellitus
- No peripheral neuropathy ≥ grade 2
- HIV-positivity allowed provided the following criteria are met:
- No history of AIDS-defining events including history of CD4 cell count <
200/mm^3
- Current CD4 cell count ≥ 350/mm^3
- Not receiving zidovudine or stavudine
- No secondary amyloidosis
- No known hypersensitivity to bortezomib, boron, or mannitol
PRIOR CONCURRENT THERAPY:
- See Disease Characteristics
- No prior chemotherapy or radiotherapy for the treatment of myeloma or systemic
light-chain amyloidosis
- More than 3 weeks since radiotherapy
- Enrollment of subjects who require radiotherapy (which must be localized in
field size) should be deferred until the radiotherapy is completed and 3 weeks
have elapsed since the last date of therapy
- More than 14 days since prior and no concurrent participation in clinical trials with
other investigational agents not included in this trial
We found this trial at
197
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