Long-term, Substantial Weight Loss and Insulin Regulation of Lipolysis
| Status: | Not yet recruiting |
|---|---|
| Conditions: | Obesity Weight Loss |
| Therapuetic Areas: | Endocrinology |
| Healthy: | No |
| Age Range: | 18 - 65 |
| Updated: | 3/13/2019 |
| Start Date: | April 1, 2019 |
| End Date: | December 31, 2025 |
It is not known how much improvement in insulin regulated lipolysis (the breakdown of
triglycerides) occurs following substantial, sustained weight loss. Researchers will test the
effects of inflammation and lipolysis regulation in people before and after bariatric surgery
(sleeve gastrectomy) to answer these questions.
triglycerides) occurs following substantial, sustained weight loss. Researchers will test the
effects of inflammation and lipolysis regulation in people before and after bariatric surgery
(sleeve gastrectomy) to answer these questions.
Inclusion Criteria:
- BMI 40 - 50 kg/m2.
- Mo active physical illness that would interfere with mobility or weight loss after
bariatric surgery
Exclusion Criteria:
- Type 1 or Type 2 Diabetes diagnosis or fasting plasma glucose ≥126 mg/dL
- Active coronary artery disease
- Participation in structured exercise (>2 times per week for 30 minutes or longer)
- Smoking
- Medications known to affect adipose tissue metabolism (e.g., beta blockers,
corticosteroids)
- Renal insufficiency (serum creatinine > 1.5mg/dl)
- Chronic active liver disease (Bilirubin > 17mmol/L, AST > 144 IU/L, or ALT>165IU/L)
- Pregnancy or breastfeeding.
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