Research Study Investigating How Well NNC0174-0833 Works in People Suffering From Overweight or Obesity.



Status:Recruiting
Conditions:Obesity Weight Loss, Obesity Weight Loss
Therapuetic Areas:Endocrinology
Healthy:No
Age Range:18 - Any
Updated:3/27/2019
Start Date:March 1, 2019
End Date:April 10, 2020
Contact:Novo Nordisk
Email:clinicaltrials@novonordisk.com
Phone:(+1) 866-867-7178

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Investigation of Safety and Efficacy of NNC0174-0833 for Weight Management - a Dose Finding Trial.

This study will look at the change in body weight in people taking NNC0174-0833, liraglutide
and "dummy" medicine, from the start to the end of the study. As well as taking the medicine,
participants will have talks with study staff about healthy food choices, how to be more
physically active and what participants can do to lose weight. Participants will either take
NNC0174-0833, liraglutide or "dummy" medicine - which treatment participants get is decided
by chance. Participants will need to take one injection once a week or once a day, depending
on the treatment. The study medicine is injected with a thin needle in a skin fold in the
stomach, thigh or upper arm. The study will last for about 8 months. Participants will have
12 clinic visits with the study doctor.


Inclusion Criteria:

- 18 years or older at the time of signing the informed consent.

- Female subject of non-childbearing potential or Male subject who is surgically
sterilised (vasectomy) or who is willing to use adequate contraceptive methods (as
required by local regulation or practice) throughout the trial (until 'end of trial').

- BMI equal to 30.0 kg/m^2 or greater or BMI equal to 27.0 kg/m^2 or greater with the
presence of at least one of the following weight-related comorbidities (treated or
untreated): hypertension or dyslipidaemia (to be assessed at the investigator's
discretion).

Exclusion Criteria:

- HbA1c equal to 48 mmol/mol (6.5 percentage) or greater as measured by the central
laboratory at screening.

- A self-reported change in body weight greater than 5 kg (11 lbs) within 90 days prior
to screening irrespective of medical records.
We found this trial at
22
sites
Franklin, Ohio 45005
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Franklin, OH
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Anaheim, California 92801
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Anaheim, CA
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Arlington, Virginia 22206
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Arlington, VA
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Bristol, Tennessee 37620
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Bristol, TN
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Calgary,
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Chicago, Illinois 60612
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Chicago, IL
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Crystal River, Florida 34429
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Crystal River, FL
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Elkridge, Maryland 21075
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Elkridge, MD
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Gaffney, South Carolina 29341
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Gaffney, SC
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Greensboro, North Carolina 27408
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Greensboro, NC
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Jacksonville, Florida 32207
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Jacksonville, FL
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Mason, OH
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Norman, Oklahoma 73069
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Norman, OK
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North Dartmouth, Massachusetts 02747
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North Dartmouth, MA
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Pembroke Pines, Florida 33026
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Pembroke Pines, FL
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Ponte Vedra, Florida 32081
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Ponte Vedra, FL
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Richmond, Virginia 23219
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Richmond, VA
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Rochester, New York 14609
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Rochester, NY
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Round Rock, Texas 78681
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Round Rock, TX
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Spartanburg, South Carolina 29303
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Spartanburg, SC
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Spring Valley, California 91978
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Spring Valley, CA
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Wadsworth, Ohio 44281
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Wadsworth, OH
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