Ciprofloxacin Versus Levofloxacin in Stem Cell Transplant
| Status: | Recruiting |
|---|---|
| Healthy: | No |
| Age Range: | 18 - 75 |
| Updated: | 2/23/2019 |
| Start Date: | March 14, 2018 |
| End Date: | March 30, 2022 |
| Contact: | shatha farhan, MD |
| Email: | SFARHAN1@HFHS.ORG |
| Phone: | 313 713 3910 |
Ciprofloxacin Versus Levofloxacin and Rate of Breakthrough Infections in Hematopoietic Stem Cell Transplant Patients
Ciprofloxacin and levofloxacin are both in guidelines to use for prophylaxis in autologous
and allogeneic Stem cell transplant.Ciprofloxacin was recently replaced by levofloxacin as
the preferred agent in some transplant centers. In some small retrospective studies
ciprofloxacin prophylaxis was associated with a higher rate of breakthrough gram positive
bloodstream infections. However, the optimum oral agent for antibacterial prophylaxis in
transplant recipients remains uncertain.
and allogeneic Stem cell transplant.Ciprofloxacin was recently replaced by levofloxacin as
the preferred agent in some transplant centers. In some small retrospective studies
ciprofloxacin prophylaxis was associated with a higher rate of breakthrough gram positive
bloodstream infections. However, the optimum oral agent for antibacterial prophylaxis in
transplant recipients remains uncertain.
Inclusion Criteria:
- Patients 18-75 years of age with a diagnosis of a hematological malignancy. Meet the
stem cell transplant program criteria to undergo autologous or allogeneic
hematopoietic stem cell transplantation.
Exclusion Criteria:
- Prolonged QT
- Allergies to ciprofloxacin or levofloxacin
We found this trial at
1
site
