Wearable Sensors for Quantitative Assessment of Motor Impairment in Huntington's Disease Huntington's Disease

The principal means of measuring motor impairment in Huntington disease (HD) is the Unified
Huntington's Disease Rating Scale (UHDRS) total motor score, which is subjective,
categorical, requires significant training to administer correctly, and only captures
impairments in clinic. In this Direct to Phase II SBIR we will develop a wearable sensor
system for objective, sensitive, and continuous assessment of Huntington's chorea during
activities of daily living. The developed technology could be used clinically to detect
changes in motor function in response to medications, or could be used scientifically to
expedite and reduce the cost of early stage pharmaceutical clinical trials.