Alzheimer's Autism and Cognitive Impairment Stem Cell Treatment Study

Cognition is the process of generating thoughts, recalling memories, processing information,
and higher order associations including social interactivity that all take place in the
brain. It requires sufficient health and interactivity of neurons in the brain including
their ability to form and maintain synaptic connections.

Cognitive impairment results from the loss of these abilities. ACIST will test the hypothesis
that the delivery of Bone Marrow Derived Stem Cells (BMSC) via the methods in the study with
or without the addition of Near Infrared Light will improve cognition through the ability of
BMSC to positively affect the health and function of neurons and the brain.

Patients enrolling with cognitive impairment will require assessment with the Mini-Mental
Status Exam (MMSE). A score of 24 or less will be required. Progressive dementias such as
Alzheimer's Disease (ALZ) show a decline of 2 to 4 points per year on MMSE. The goal for
ACIST in progressive and stable dementia will be stability over the 1 year follow up and
ideally an improvement of 3 points on MMSE.

Patients enrolling with Autism Spectrum Disorder (ASD) will be required to be adults (over 18
years of age) and to have a score on the Autism Spectrum Quotient of 20 or above. The goal
will be a decrease of 5 or more on the scale over the 1 year follow up period.

Inclusion Criteria:

1. Have documented cognitive impairment or diagnosis of disease associated with cognitive
impairment such as Alzheimer's Disease, Autism Spectrum Disorder.

2. If under current medical therapy (pharmacologic or surgical treatment) for the
condition be considered stable on that treatment and unlikely to have reversal of the
associated cognitive impairment as a result of the ongoing pharmacologic or surgical
treatment.

3. In the estimation of the investigator have the potential for improvement with BMSC
treatment and be at minimal risk of any potential harm from the procedure.

4. Be over the age of 18

5. Be medically stable and able to be medically cleared by their primary care physician
or a licensed primary care practitioner for the procedure. Medical clearance means
that in the estimation of the primary care practitioner, the patient can reasonably be
expected to undergo the procedure without significant medical risk to health.

Exclusion Criteria:

1. All patients must be capable of an adequate neurologic examination and evaluation to
document the pathology.

2. Patients must be capable and willing to undergo follow up neurologic exams with the
the investigators or their own neurologists as outlined in the protocol.

3. Patients or their designated responsible party for medical decisions must be capable
of providing informed consent. Cognitive or memory impairment does not necessarily
mean the patient is incapable of giving informed consent. They may simply need more
time to process or repetition of the content of the consent to reach understanding and
provide informed consent.

4. In the estimation of the investigator the BMSC collection and treatment will not
present a significant risk of harm to the patient's general health or to their
neurologic function.

5. Patients who are not medically stable or who may be at significant risk to their
health undergoing the procedure will not be eligible.

6. Women of childbearing age must not be pregnant at the time of treatment and should
refrain from becoming pregnant for 3 months post treatment.