Heart Inflammation and Mental Stress Study
| Status: | Not yet recruiting |
|---|---|
| Conditions: | High Blood Pressure (Hypertension), Psychiatric |
| Therapuetic Areas: | Cardiology / Vascular Diseases, Psychiatry / Psychology |
| Healthy: | No |
| Age Range: | 21 - 65 |
| Updated: | 1/20/2019 |
| Start Date: | April 1, 2019 |
| End Date: | February 2023 |
| Contact: | Roger C McIntosh, Ph.D. |
| Email: | r.mcintosh@miami.edu |
| Phone: | 305-243-2047 |
The main objectives of the study are to assess (1) patterns of brain activity/connectivity
that confers greater cardio-autonomic/emotion regulation, (e.g., heart rate variability,
blood pressure reactivity, inflammatory-immune activation, etc.), during rest, mental stress,
and anger-related distress, (2) whether changes in breathing pace mitigate task-based effects
on cardio-autonomic-immune regulation, and (3) whether these patterns vary as a function of
HIV or pre-hypertensive (HTN) status-related changes to the brain structures underlying
cardioautonomic and emotion regulation.
that confers greater cardio-autonomic/emotion regulation, (e.g., heart rate variability,
blood pressure reactivity, inflammatory-immune activation, etc.), during rest, mental stress,
and anger-related distress, (2) whether changes in breathing pace mitigate task-based effects
on cardio-autonomic-immune regulation, and (3) whether these patterns vary as a function of
HIV or pre-hypertensive (HTN) status-related changes to the brain structures underlying
cardioautonomic and emotion regulation.
Inclusion criteria:
1. pre-hypertension screening.
2. HIV-antibody testing.
Exclusion criteria:
1. current use of anti-lipid, antihypertensive, or heart rate altering medications;
2. current or lifetime history of cardiovascular disease diagnosis or treatment including
pulmonary stenosis, heart valve abnormalities and hypertension;
3. current or lifetime diagnoses of cancer, kidney/liver disease, hypertension, Type 1 or
Type 2 diabetes;
4. history of trauma, cerebral infarction or hemorrhage;
5. current diagnosis and/or treatment for hypertension;
6. severe cognitive impairment;
7. current treatment or diagnosis of psychiatric illness;
8. metal implants or debris within the body; or pregnancy;
9. body mass index > 35;
10. use of hormone replacement therapy; and current smoker.
We found this trial at
1
site
Miami, Florida 33124
(305) 284-2211
Principal Investigator: Roger C McIntosh, PhD
Phone: 305-243-2047
University of Miami A private research university with more than 15,000 students from around the...
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