Total Knee Arthroplasty Biomechanics



Status:Not yet recruiting
Healthy:No
Age Range:18 - 90
Updated:2/10/2019
Start Date:April 10, 2019
End Date:December 30, 2020

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Determining the Effects of Implant Design, Soft Tissue Balance, Neuromuscular Adaptations, and Rehabilitation Strategies on Functional Outcomes and Patient Satisfaction After Total Knee Arthroplasty

In total knee arthroplasty (TKA), the relationship between implant design, soft tissue
balance, neuromuscular contributions, and rehabilitation strategies on patient satisfaction
and functional outcomes is highly complex and poorly understood. The investigators will
prospectively study the effects of these factors using in vivo assessments preoperatively,
and postoperatively. Computer simulation models will also be used to analyze lower extremity
biomechanics.

Total knee arthroplasty (TKA) is the primary treatment for end-stage knee osteoarthritis and
effectively relieves pain and improves function after surgery. Nevertheless, as many as 1 in
5 patients are dissatisfied with the postoperative outcome, and knee instability remains one
of the top indications for revision surgery. Implant design, soft tissue balance,
neuromuscular capabilities, and rehabilitation strategies can all influence postoperative
outcomes. However, the relationship between these factors and the most effective therapeutic
approach for total knee arthroplasty has yet to be identified. The investigators will study
preoperative and postoperative functional measures and patient satisfaction along with
implant design and specific intraoperative data, which may help inform a targeted approach
for optimal outcomes after total knee arthroplasty and improve future care of patients.

Inclusion Criteria:

- Patients requiring unilateral TKA for knee osteoarthritis

- Contralateral knee with Kellgren-Lawrence grade ≤1

- Radiographic coronal deformity ≤ 15°

- Preoperative flexion ≥ 90°

- Receiving one of four implants used by UF Orthopaedic surgeons

- Able to walk for a short distance without the use of ambulatory aids

- Healthy Participants:

1. Age 49-85 years

2. Healthy with no signs or symptoms of lower limb arthritis or injury

3. Able to walk for a short distance without the use of ambulatory aids

Exclusion Criteria:

- BMI > 40 kg/m2

- Presence of knee, hip, or ankle prosthesis for either limb

- History of lower limb or spinal surgery

- Presence of neurologic or orthopaedic disorders that could affect gait or balance

- Chronic opioid or illicit drug use

- Poorly controlled diabetes (HbA1C > 7 percent)

- Chronic pain syndrome

- Chronic back pain

- Diagnosed anxiety or depressive disorders

- Presence of vestibular disorder

- Pregnancy
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Gainesville, Florida 32608
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3450 Hull Road
Gainesville, Florida 32611
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2033 Mowry Road
Gainesville, Florida 32610
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