MRI of the Pancreas in Type 1 Diabetes
| Status: | Recruiting |
|---|---|
| Conditions: | Diabetes |
| Therapuetic Areas: | Endocrinology |
| Healthy: | No |
| Age Range: | 8 - 60 |
| Updated: | 7/14/2018 |
| Start Date: | February 19, 2014 |
| End Date: | June 2043 |
| Contact: | Jonathan M Williams, PhD |
| Email: | jon.williams@vumc.org |
| Phone: | 6158759200 |
Development of 3T MRI/MRS Applications for Diabetes Research
This research applies new magnetic resonance imaging (MRI) techniques to study the pancreas
of patients who were recently diagnosed with type 1 diabetes (T1D). The MRI techniques used
include both standard anatomical imaging, which has shown that pancreas size is smaller in
patients with T1D, as well as advanced quantitative MRI techniques that have not previously
been used to study the pancreas in T1D. These advanced MRI techniques image the structure and
chemical composition of the body and may be sensitive to changes in the pancreas that occur
during T1D. MRI is performed three times in the first year after diagnosis of type 1 diabetes
to determine changes in the pancreas that occur as disease progresses. Patients without T1D
are also imaged with these advanced MRI techniques to determine differences in the pancreas
in people with T1D. The advanced MRI techniques may discover changes that occur in the
pancreas with type 1 diabetes that are currently not known. Discovery of unknown changes may
lead to new ways to treat disease. The MRI techniques may also be useful for following how
T1D is progressing in different people, determining whether new drugs are effective, and
ultimately detecting T1D in people earlier than currently possible.
of patients who were recently diagnosed with type 1 diabetes (T1D). The MRI techniques used
include both standard anatomical imaging, which has shown that pancreas size is smaller in
patients with T1D, as well as advanced quantitative MRI techniques that have not previously
been used to study the pancreas in T1D. These advanced MRI techniques image the structure and
chemical composition of the body and may be sensitive to changes in the pancreas that occur
during T1D. MRI is performed three times in the first year after diagnosis of type 1 diabetes
to determine changes in the pancreas that occur as disease progresses. Patients without T1D
are also imaged with these advanced MRI techniques to determine differences in the pancreas
in people with T1D. The advanced MRI techniques may discover changes that occur in the
pancreas with type 1 diabetes that are currently not known. Discovery of unknown changes may
lead to new ways to treat disease. The MRI techniques may also be useful for following how
T1D is progressing in different people, determining whether new drugs are effective, and
ultimately detecting T1D in people earlier than currently possible.
Exclusion Criteria:
- Subjects under 8 years of age or over 60 years of age.
- Subjects with pancreatitis, cystic fibrosis, pancreatic adenocarcinoma, or
neuroendocrine tumors
- Subjects with T1D with body mass index > 90th percentile for age
- Body mass index > 40
- Subjects who have any type of bioimplant activated by mechanical, electronic, or
magnetic means (e.g., cochlear implants, pacemakers, neurostimulators, biostimulators,
electronic infusion pumps, etc), because such devices may be displaced or malfunction.
- Subjects who have any type of ferromagnetic bioimplant that could potentially be
displaced.
- Subjects who have cerebral aneurysm clips.
- Subjects who may have shrapnel imbedded in their bodies (such as from war wounds),
metal workers and machinists (potential for metallic fragments in or near the eyes).
- Subjects who are pregnant, plan to become pregnant within the next year, or are
breast-feeding. Urine pregnancy test will be performed on women of child bearing
potential that are not practicing appropriate contraception measures or menstruating.
- Subjects who exhibit noticeable anxiety and/or claustrophobia or who exhibit severe
vertigo when they are moved into the magnet bore.
- Subjects incapable of giving assent/informed written consent due to the following
reasons:
- Inability to adhere to the experimental protocols for any reason
- Inability to communicate with the research team
- Limited ability to give informed consent due to mental disability, altered mental
status, confusion, or psychiatric disorders
- Prisoners or other individuals deemed to be susceptible to coercion
We found this trial at
1
site
1211 Medical Center Dr
Nashville, Tennessee 37232
Nashville, Tennessee 37232
(615) 322-5000
Principal Investigator: Alvin C Powers, MD
Phone: 615-875-9200
Vanderbilt Univ Med Ctr Vanderbilt University Medical Center (VUMC) is a comprehensive healthcare facility dedicated...
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