Abdominal Nerve Blockade in Chronic Heart Failure.



Status:Recruiting
Conditions:Cardiology
Therapuetic Areas:Cardiology / Vascular Diseases
Healthy:No
Age Range:18 - Any
Updated:3/1/2019
Start Date:May 1, 2018
End Date:May 1, 2020
Contact:Manesh Patel
Email:manesh.patel@duke.edu
Phone:(919) 681-5816

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Splanchnic Nerve Blockade in Chronic Heart Failure. Splanchnic CHF

Patients with chronic heart failure and undergoing right heart catheterization will be
enrolled in this study. Subjects will undergo catheterization of the heart to obtain central
cardiac pressure and other cardiac hemodynamic parameters. Subsequently, the subject will
undergo a regional nerve block of the splanchnic nerves.

This study will be a prospective, uncontrolled clinical trial. The study will not be
controlled as invasive monitoring of hemodynamics will be performed, allowing clear
demonstration of a cause-effect relationship. The goal of the study is to provide proof of
concept.

Patients will undergo detailed physiological testing.


Inclusion Criteria:

- Diagnosis of heart failure (HF)

- Symptomatic with dyspnea

- On a stable HF drug regimen

Exclusion Criteria:

- Ongoing treatment with oral anticoagulation other than aspirin

- Immunosuppressive medications for solid organ transplant

- Acute MI (STEMI or Type I NSTEMI) within 7 days

- Systolic blood pressure < 90 mmHg or >180 mmHg

- Infiltrative cardiomyopathy or constrictive cardiomyopathy

- Chronic kidney disease stage 5

- Pregnancy
We found this trial at
1
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Durham, North Carolina 27710
Phone: 919-681-5816
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Durham, NC
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