Evaluate ALLN-177 in Patients With Enteric Hyperoxaluria



Status:Recruiting
Healthy:No
Age Range:18 - Any
Updated:4/6/2019
Start Date:May 21, 2018
End Date:October 2019
Contact:Allena Pharmaceuticals, Inc
Email:clinical301@allenapharma.com
Phone:617-467-4577

Use our guide to learn which trials are right for you!

Evaluate the Safety and Efficacy of ALLN-177 in Patients With Enteric Hyperoxaluria: A Phase III Randomized, Placebo-Controlled Study

The purpose of this study is to determine the efficacy and safety of ALLN-177 in patients
with enteric hyperoxaluria.

This is a phase 3, multicenter, randomized, double-blind, placebo-controlled study. This
study is designed to determine whether treatment with ALLN-177 for 28 days can reduce urinary
oxalate excretion in patients with enteric hyperoxaluria and to evaluate the safety of
ALLN-177 in this patient population compared to placebo.

Inclusion Criteria:

1. Provided informed consent

2. Age 18 or older

3. History of hyperoxaluria secondary to a known underlying enteric disorder associated
with malabsorption (e.g., bariatric surgery, Crohn's disease, short bowel syndrome, or
other malabsorption syndrome)

4. Urinary Oxalate ≥ 50mg/24h

Exclusion Criteria:

1. Acute renal failure or estimated glomerular filtration rate (eGFR) < 30mL/min/1.73 m2

2. Unable or unwilling to discontinue Vitamin C supplementation
We found this trial at
38
sites
Raleigh, North Carolina 27607
?
mi
from
Raleigh, NC
Click here to add this to my saved trials
185 Cambridge Street
Boston, Massachusetts 02114
617-724-5200
?
mi
from
Boston, MA
Click here to add this to my saved trials
Chapel Hill, North Carolina 27599
(919) 962-2211
University of North Carolina at Chapel Hill Carolina’s vibrant people and programs attest to the...
?
mi
from
Chapel Hill, NC
Click here to add this to my saved trials
1211 Medical Center Dr
Nashville, Tennessee 37232
(615) 322-5000
Vanderbilt Univ Med Ctr Vanderbilt University Medical Center (VUMC) is a comprehensive healthcare facility dedicated...
?
mi
from
Nashville, TN
Click here to add this to my saved trials
201 Presidents Circle
Salt Lake City, Utah 84108
801) 581-7200
University of Utah Research is a major component in the life of the U benefiting...
?
mi
from
Salt Lake City, UT
Click here to add this to my saved trials
Bakersfield, California 93311
?
mi
from
Bakersfield, CA
Click here to add this to my saved trials
Birmingham, Alabama 35209
?
mi
from
Birmingham, AL
Click here to add this to my saved trials
?
mi
from
Birmingham, AL
Click here to add this to my saved trials
Chicago, Illinois 60607
?
mi
from
Chicago, IL
Click here to add this to my saved trials
Cincinnati, Ohio 45212
?
mi
from
Cincinnati, OH
Click here to add this to my saved trials
Coeur d'Alene, Idaho 83814
?
mi
from
Coeur d'Alene, ID
Click here to add this to my saved trials
Dallas, Texas 75235
?
mi
from
Dallas, TX
Click here to add this to my saved trials
545 Health Boulevard
Daytona Beach, Florida 32114
?
mi
from
Daytona Beach, FL
Click here to add this to my saved trials
2301 Erwin Rd
Durham, North Carolina 27710
919-684-8111
Duke Univ Med Ctr As a world-class academic and health care system, Duke Medicine strives...
?
mi
from
Durham, NC
Click here to add this to my saved trials
11400 University Avenue
Edmonton, Alberta T6G 1Z1
?
mi
from
Edmonton,
Click here to add this to my saved trials
7580 Buckingham Boulevard
Hanover, Maryland 21076
?
mi
from
Hanover, MD
Click here to add this to my saved trials
Houston, Texas 77027
?
mi
from
Houston, TX
Click here to add this to my saved trials
Houston, Texas 77024
?
mi
from
Houston, TX
Click here to add this to my saved trials
1801 Senate Boulevard
Indianapolis, Indiana 46202
?
mi
from
Indianapolis, IN
Click here to add this to my saved trials
Jacksonville, Florida 32216
?
mi
from
Jacksonville, FL
Click here to add this to my saved trials
Little Rock, Arkansas 72212
?
mi
from
Little Rock, AR
Click here to add this to my saved trials
Maitland, Florida 32751
?
mi
from
Maitland, FL
Click here to add this to my saved trials
Meridian, Idaho 83642
?
mi
from
Meridian, ID
Click here to add this to my saved trials
Miami, Florida 33186
?
mi
from
Miami, FL
Click here to add this to my saved trials
103 East 75th Street
New York, New York 10021
?
mi
from
New York, NY
Click here to add this to my saved trials
630 W 168th St
New York, New York
212-305-2862
Columbia University Medical Center Situated on a 20-acre campus in Northern Manhattan and accounting for...
?
mi
from
New York, NY
Click here to add this to my saved trials
Omaha, Nebraska 68118
?
mi
from
Omaha, NE
Click here to add this to my saved trials
Phoenix, Arizona
?
mi
from
Phoenix, AZ
Click here to add this to my saved trials
Plainview, New York 11803
?
mi
from
Plainview, NY
Click here to add this to my saved trials
Portland, Maine 04102
?
mi
from
Portland, ME
Click here to add this to my saved trials
Richmond, Virginia 23235
?
mi
from
Richmond, VA
Click here to add this to my saved trials
Rochester, Minnesota 55905
?
mi
from
Rochester, MN
Click here to add this to my saved trials
Rockport, Maine 04856
?
mi
from
Rockport, ME
Click here to add this to my saved trials
Shreveport, Louisiana 71106
?
mi
from
Shreveport, LA
Click here to add this to my saved trials
Toledo, Ohio 43606
?
mi
from
Toledo, OH
Click here to add this to my saved trials
?
mi
from
Tucson, AZ
Click here to add this to my saved trials
Virginia Beach, Virginia 23462
?
mi
from
Virginia Beach, VA
Click here to add this to my saved trials
Wilmington, North Carolina 28401
?
mi
from
Wilmington, NC
Click here to add this to my saved trials