The Role of High Intensity Interval Training in the Treatment of Adolescent Obesity

Adolescents will be randomized to a 12-week lifestyle intervention including behavioral and
dietary interventions, and one of two exercise training conditions, HIIT or CMIT).
Adolescents in the HIIT treatment will participate in treadmill exercise in 1-minute
intervals of challenging intensities with recovery periods in between, gradually increasing
the number of intervals over the course of the study. Adolescents in the CMIT treatment will
participate in a constant moderate intensity treadmill exercise, gradually increasing the
duration of the exercise over the course of the study.

Both parents and teens will have height and weight measurements taken, complete behavior
questionnaires and wear an activity monitor for one week at baseline, 12 weeks and 16 weeks.

Adolescents will have a physical exam by a study medical provider before starting the
intervention. Adolescents will also have blood work, an oral glucose tolerance test, an
electrocardiogram, body composition measurements and a maximal graded exercise test done at
baseline, and again at one or more time points. Adolescents will also complete a detailed
food log at those time points.

Adolescents will exercise at the study gym 3 evenings a week for 12 weeks. On one of those
evenings teens will also attend a 60-minute individual behavioral weight management session.
Nine of these are with a behavior coach, and 3 with a dietitian. Parents will also attend one
introductory session with the behavior coach, join the teen for the 3 sessions with the
dietitian, and review adolescent individual goals and identify parent support goals at the
end of each behavior session.

Inclusion Criteria:

- Age of 12 to 16 years with obesity (BMI ≥95% percentile for age and gender according
to the CDC Growth Charts).

- Have a parent (or legal guardian) who is willing to provide basic demographic
information, complete required surveys, and attend portions of the weekly
adolescent-focused behavioral weight management sessions.

- Participating parent must reside with the adolescent within a 30-mile distance of the
study site.

Exclusion Criteria:

- Non-English speaking;

- Weight >300 lbs;

- Medical condition(s) that may be associated with unintentional weight change (e.g.,
hypothalamic injury, Prader-Willi, untreated thyroid disease or malignancy);

- Diabetes mellitus diagnosed by history or a fasting glucose ≥126 mg/dl (subjects with
glucose intolerance or "prediabetes" will eligible for study participation);

- Use of insulin sensitizing agents (e.g. metformin), antihypertensive medications,
medications for treatment of hyperlipidemia, oral contraceptives, oral
glucocorticoids, atypical antipsychotics, weight loss medications, or an
investigational medication within 3 months of study participation;

- Medical condition(s) that may be negatively impacted by high-intensity exercise
training;

- Psychiatric, cognitive, developmental or physical conditions that would impair the
adolescent's ability to complete assessments, participate in behavioral weight
management sessions, or conduct physical activity;

- Reports of compensatory behaviors (i.e., vomiting, laxative abuse, excessive exercise)
in the past 3 months;

- Current pregnancy or plan to become pregnant during study period;

- Previous participation in the TEENS study at Virginia Commonwealth University;

- Current participation in another weight loss program; or

- Personal history of weight loss surgery;