Myocardial Perfusion Echocardiography to Detect Human Heart Transplant Rejection
| Status: | Recruiting |
|---|---|
| Conditions: | Cardiology |
| Therapuetic Areas: | Cardiology / Vascular Diseases |
| Healthy: | No |
| Age Range: | 18 - 75 |
| Updated: | 2/3/2018 |
| Start Date: | January 2015 |
| End Date: | December 2019 |
| Contact: | Michael Givertz, MD |
| Phone: | 617-525-7052 |
Myocardial Perfusion Echocardiography to Detect Human Heart Transplant
The primary objective of this proposal is to show the efficacy of contrast enhanced
ultrasonography in detecting heart transplant rejection in humans. The secondary objective is
to demonstrate the efficacy of this technique in generating data which allow for the
assessment of short and long term outcomes.
ultrasonography in detecting heart transplant rejection in humans. The secondary objective is
to demonstrate the efficacy of this technique in generating data which allow for the
assessment of short and long term outcomes.
Inclusion Criteria:
- All adult subjects (ages 18 to 75) who have undergone heart transplant at Brigham and
Women's Hospital
Exclusion Criteria:
- hemodynamic instability (e.g., systolic blood pressure < 90 mmHg)
- atrial fibrillation with rapid ventricular response (e.g., heart rate > 120 bpm)
- premature atrial or ventricular complexes of a frequency that will not allow adequate
echocardiographic assessment
- poor acoustic windows
- inability to provide informed consent
- any contraindication listed in the Optison package insert (i.e., history of an
allergic reaction)
We found this trial at
1
site
75 Francis street
Boston, Massachusetts 02115
Boston, Massachusetts 02115
(617) 732-5500
Phone: 617-525-7052
Brigham and Women's Hosp Boston’s Brigham and Women’s Hospital (BWH) is an international leader in...
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