An Investigational Immuno-Therapy Study of Experimental Medication BMS-986253 Given in Combination With Nivolumab in Patients With Advanced Cancers



Status:Recruiting
Conditions:Cancer, Cancer
Therapuetic Areas:Oncology
Healthy:No
Age Range:18 - Any
Updated:4/5/2019
Start Date:January 31, 2018
End Date:November 26, 2023
Contact:Recruiting sites have contact information. Please contact the sites directly. If there is no contact information,
Email:Clinical.Trials@bms.com
Phone:please email:

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A Phase 1/2a Study of BMS-986253 in Combination With Nivolumab in Advanced Cancers

The purpose of this study is to investigate experimental medication BMS-986253 in combination
with Nivolumab in patients with advanced cancers.


For more information regarding Bristol-Myers Squibb Clinical Trial participation, please
visit www.BMSStudyConnect.com

Inclusion Criteria:

- Histologic or cytologic confirmation of a solid tumor that is advanced (metastatic,
recurrent and/or unresectable) with measurable disease per RECIST v1.1

- At least 1 lesion accessible for biopsy

- Eastern Cooperative Oncology Group Performance Status of 0 or 1

Exclusion Criteria:

- Participants with CNS metastases as the only site of active disease (Participants with
controlled brain metastases; however, will be allowed to enroll)

- Participants with active, known or suspected autoimmune disease

- Participants with conditions requiring systemic treatment with either corticosteroids
(> 10mg prednisone equivalents) or other immunosuppressive medications within 14 days
of study treatment administration

- Participants with a known history of testing positive for Human Immunodeficiency Virus
(HIV) or known Acquired Immunodeficiency Syndrome (AIDS)

- Cytotoxic agents, unless at least 4 weeks have elapsed from last dose of prior
anti-cancer therapy and initiation of study therapy

Other protocol defined inclusion/exclusion criteria could apply
We found this trial at
24
sites
Tyler, Texas 75702
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1500 E Medical Center Dr
Ann Arbor, Michigan 48109
(734) 936-4000
University of Michigan Health System The University of Michigan is home to one of the...
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Ann Arbor, MI
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Austin, Texas 78731
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Austin, TX
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99-101 Belliardstraat
Bruxelles, 1040
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Bruxelles,
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Dallas, TX
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Denver, Colorado 80218
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Denver, CO
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Eugene, OR
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8503 Arlington Blvd., Ste. 400
Fairfax, Virginia 22031
(703) 280-5390
Virginia Cancer Specialists, PC Now the world's most advanced cancer treatment capabilities can be found...
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Fairfax, VA
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Fort Worth, Texas 76104
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Fort Worth, TX
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Greenville, South Carolina 29615
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Greenville, SC
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92 2nd St
Hackensack, New Jersey 07601
(201) 996-5900
John Theurer Cancer Center at the Hackensack University Medical Center The mission of the John...
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Hackensack, NJ
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Houston, Texas 77030
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Houston, TX
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9280 W. Sunset Road Suite 100
Las Vegas, Nevada 89148
702.952.1251
Comprehensive Cancer Centers of Nevada Comprehensive Cancer Centers of Nevada (CCCN) is the award-winning multidisciplinary...
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Las Vegas, NV
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Lutherville, MD
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Miami Beach, Florida 33140
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Miami Beach, FL
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New Brunswick, New Jersey 08903
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New Brunswick, NJ
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New York, NY
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1428 Madison Ave
New York, New York 10029
(212) 241-6500
Icahn School of Medicine at Mount Sinai Icahn School of Medicine at Mount Sinai is...
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New York, NY
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5900 Lake Wright Dr
Norfolk, Virginia 23502
(757) 466-8683
Virginia Oncology Associates Virginia Oncology Associates is an oncology and hematology practice of physicians, specializing...
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Norfolk, VA
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Oklahoma City, Oklahoma 73104
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Oklahoma City, OK
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Philadelphia, Pennsylvania 19102
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Philadelphia, PA
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Pittsburgh, Pennsylvania 15232
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Pittsburgh, PA
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Rockville, Maryland 20850
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Rockville, MD
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San Antonio, TX
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