Vitamin D and Immune Mechanisms of Hypertension in Type 2 Diabetics
| Status: | Recruiting |
|---|---|
| Conditions: | High Blood Pressure (Hypertension), Other Indications, Gastrointestinal, Diabetes, Diabetes |
| Therapuetic Areas: | Cardiology / Vascular Diseases, Endocrinology, Gastroenterology, Other |
| Healthy: | No |
| Age Range: | 25 - 80 |
| Updated: | 1/20/2018 |
| Start Date: | September 1, 2017 |
| End Date: | December 31, 2020 |
| Contact: | Veronica Worth, MD |
| Email: | cbernal@wustl.edu |
| Phone: | 3143620934 |
This trial will evaluate whether a particular type of circulating white blood cell,
monocytes, from type 2 diabetics with high blood pressure and vitamin D deficiency vs.
sufficiency will induce hormones that increase blood pressure.
monocytes, from type 2 diabetics with high blood pressure and vitamin D deficiency vs.
sufficiency will induce hormones that increase blood pressure.
More than half of patients with type 2 diabetes mellitus develop hypertension, which doubles
their risk for cardiovascular disease. Inflammation plays a role in the development of these
diseases, and monocytes, a type of white blood cell, may be critical. This study will isolate
monocytes from blood samples of patients with type 2 diabetes and high blood pressure who
have either high levels of vitamin D or low levels of vitamin D, and determine what their
effects are on stimulating production in kidney cells of a hormone that increases blood
pressure.
their risk for cardiovascular disease. Inflammation plays a role in the development of these
diseases, and monocytes, a type of white blood cell, may be critical. This study will isolate
monocytes from blood samples of patients with type 2 diabetes and high blood pressure who
have either high levels of vitamin D or low levels of vitamin D, and determine what their
effects are on stimulating production in kidney cells of a hormone that increases blood
pressure.
Inclusion Criteria:
- Type 2 diabetes (T2DM)
- Age: 25-80 years old
- Vitamin 25(OH)D3 levels <20 or >30 ng/ml.
- HbA1c: 5.5%-9.5%
- Blood Pressure: <160/100 mm Hg on BP lowering medications and
- Blood Pressure: >120/80 to 160/100 mmHg without BP lowering medications
Exclusion Criteria:
- Recent weight loss of more than 5% within 3 months prior to screening
- Current Pregnancy
- Hypercalcemia
- Previous heart attack and stroke
- Heart failure
- Atrial fibrillation
- Heavy alcohol consumption
- Extreme diets (Atkins, South Beach)
- Chronic renal failure: stage 4 or worse
- >2 + proteinuria on urine sample
- Chronic diseases known to affect immunity
We found this trial at
2
sites
4921 Parkview Place
Saint Louis, Missouri 63110
Saint Louis, Missouri 63110
Phone: 314-362-0934
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Saint Louis, Missouri 63110
Principal Investigator: Carlos Bernal-Mizrachi, MD
Phone: 314-362-0934
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