Human Mesenchymal Stem Cells in the Synovial Fluid of the Hip
| Status: | Recruiting |
|---|---|
| Conditions: | Orthopedic |
| Therapuetic Areas: | Orthopedics / Podiatry |
| Healthy: | No |
| Age Range: | 18 - 90 |
| Updated: | 3/9/2019 |
| Start Date: | September 2016 |
| End Date: | November 2021 |
| Contact: | Cox Teron |
| Email: | Cox.Teron@mayo.edu |
| Phone: | (507) 538-3560 |
Human Mesenchymal Stem Cells in the Synovial Fluid of the Hip in Patients With Osteonecrosis of the Femoral Head
Previous studies have shown an increase in the concentration of mesenchymal stem cells
(MSC's) in the setting of osteoarthritis of the knee and its correlation to severity.
Researchers have shown that as there is an increase in the severity of the disease, the
concentration of stem cells also increases. The purpose of this study is to determine if
there is the same increase in stem cell concentration in patients with osteonecrosis (ON) of
the femoral head.
(MSC's) in the setting of osteoarthritis of the knee and its correlation to severity.
Researchers have shown that as there is an increase in the severity of the disease, the
concentration of stem cells also increases. The purpose of this study is to determine if
there is the same increase in stem cell concentration in patients with osteonecrosis (ON) of
the femoral head.
Since the treatment of osteonecrosis is related to the severity of disease, namely articular
cartilage collapse, the purpose of this study is to determine if the MSC concentration in
synovial fluid can be correlated to disease stage. In order to do this the investigators
will:
Milestone #1:
Determine the concentration of MSC's in the synovial fluid in patients with osteonecrosis.
This work will be carried out utilizing FACS-based technique to synovial fluid stem cell
sub-population.
Milestone #2:
Compare concentrations of MSC's in patients with pre collapse, post collapse osteonecrosis
and "normal" hips. Patient-derived MSC will be quantified at the different stages of disease
and assays will be performed in order to assess their viability. A control group will be
selected in patients undergoing hip arthroscopy for femoral/acetabular impingement (FAI).
Since FAI does not affect the intraarticular environment of the hip, theoretically these
patients would have a "normal" concentration of synovial stem cells.
cartilage collapse, the purpose of this study is to determine if the MSC concentration in
synovial fluid can be correlated to disease stage. In order to do this the investigators
will:
Milestone #1:
Determine the concentration of MSC's in the synovial fluid in patients with osteonecrosis.
This work will be carried out utilizing FACS-based technique to synovial fluid stem cell
sub-population.
Milestone #2:
Compare concentrations of MSC's in patients with pre collapse, post collapse osteonecrosis
and "normal" hips. Patient-derived MSC will be quantified at the different stages of disease
and assays will be performed in order to assess their viability. A control group will be
selected in patients undergoing hip arthroscopy for femoral/acetabular impingement (FAI).
Since FAI does not affect the intraarticular environment of the hip, theoretically these
patients would have a "normal" concentration of synovial stem cells.
Inclusion Criteria:
- Patients consented to undergo a THA (post-collapse osteonecrosis), hip arthroscopy or
minimally invasive core decompression
- Preoperative radiographic diagnosis of ON or FAI (femoral/acetabular impingement)
Exclusion Criteria:
- Pregnant females
- Active infection, HIV, Hepatitis C or B, syphilis Immunodeficiency
- Patients receiving hematopoetic growth factors or anti-angiogenesis products
We found this trial at
1
site
Rochester, Minnesota 55905
Principal Investigator: Raphael J. Sierra, M.D.
Phone: 507-538-3560
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