Study to Evaluate Amifampridine Phosphate in Patients With MuSK-MG

Randomized, double-blind, placebo-controlled, parallel group study is designed to evaluate
the safety, tolerability and efficacy of amifampridine phosphate in patients with MuSK-MG. In
addition, a sample of AChR-MG patients will be assess for efficacy and safety of
amifampridine phosphate. Planned duration of participation for each patient is at least 38
days, excluding the screening period. Eligible patients will be titrated to an efficacious
dose of amifampridine phosphate and those who demonstrate improvement will be randomized to
either placebo or amifampridine, in a double-blind fashion, for 10 days.

Inclusion Criteria:

1. Willing and able to provide written informed consent after the nature of the study has
been explained and before the start of any research-related procedures.

2. Male or female ≥18 years of age.

3. Positive serologic test for anti-MuSK antibodies or anti-AChR antibodies as confirmed
at Screening or by previous antibody test, with report available.

4. Confirmatory EMG or EMG report.

5. Myasthenia Gravis Foundation of America (MGFA) Class II to IV at Screening.

6. MG-ADL score of ≥6 at Screening, with more than 50% of this score attributed to
non-ocular items.

7. Patients receiving steroids or pyridostigmine should not have any modification of drug
regimen during the month before Screening.

8. Female patients of childbearing potential must have a negative pregnancy test (serum
human chorionic gonadotropin [HCG] at screening); and must practice an effective,
reliable contraceptive regimen during the study and for up to 30 days following
discontinuation of treatment.

9. Ability to participate in the study based on overall health of the patient and disease
prognosis, as applicable, in the opinion of the Investigator; and able to comply with
all requirements of the protocol, including completion of study questionnaires.

Exclusion Criteria:

1. Epilepsy and currently on medication.

2. Concomitant use of medicinal products with a known potential to cause QTc
prolongation.

3. Patients with long QT syndromes.

4. History of thymectomy within 12 months before Screening.

5. An electrocardiogram (ECG) within 6 months before starting treatment that shows
clinically significant abnormalities, in the opinion of the Investigator.

6. Breastfeeding or pregnant at Screening or planning to become pregnant at any time
during the study.

7. Patients receiving immunomodulatory treatment (e.g. plasma exchange [PE], therapeutic
plasma exchange [TPE], intravenous immunoglobulin G [IVIG]) should not have any
treatment in the previous 4 weeks prior to Randomization or at any time during the
study.

8. Use of rituximab or other similar biologic medications for immunomodulation within 6
months prior to Screening.

9. Treatment with an investigational drug (other than amifampridine) or device within 30
days before Screening or while participating in this study.

10. Any medical condition that, in the opinion of the Investigator, might interfere with
the patient's participation in the study, poses an added risk for the patient, or
confound the assessment of the patient.

11. History of drug allergy to any pyridine-containing substances or any amifampridine
excipient(s).