Extracellular RNA Markers of Liver Disease and Cancer



Status:Recruiting
Conditions:Liver Cancer, Cancer, Cancer, Cancer, Gastrointestinal
Therapuetic Areas:Gastroenterology, Oncology
Healthy:No
Age Range:18 - Any
Updated:12/9/2018
Start Date:July 2014
End Date:July 2020
Contact:Lori A Chase, CCRP
Email:chase.lori@mayo.edu
Phone:904-953-3464

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The study will examine and evaluate the use of extracellular RNA in blood as markers for the
diagnosis of liver disease or cancer, and as markers for prediction of response to treatment
or recurrence of cancer after surgery

The goal is to identify an extracellular RNA candidate for the detection and diagnosis of
liver cancers such as hepatocellular cancer or biliary cancer, and chronic liver diseases.
The use of selected exRNA biomarkers for diagnosis of hepatocellular cancer (HCC) or biliary
tract cancers in patients with cirrhosis will be evaluated in a prospective case-control
study. The study will create a registry of patients who have chronic liver disease,
cirrhosis, liver and biliary tract cancers. A risk factor questionnaire will be administered
to facilitate identification of risk factors for development of liver cancer. Patient
information will be obtained from the medical record, and include demographics, medical
history, liver disease, smoking and alcohol history, etiology, family history, and clinical
laboratory data.

Inclusion Criteria:

- Lab results from within the previous 90 days.

- Diagnosis of HCC or biliary tract cancer

- Diagnosis of cirrhosis based on histology, imaging, or ultrasound.

- Diagnosis of a chronic liver disease without cirrhosis.

Exclusion Criteria for the HCC/biliary tract cancer group:

- Prior solid organ transplant.

- Previous cancer history with the last 5 years (excluding non-melanoma skin cancer),
participation in a treatment trial for HCC

Exclusion criteria for the cirrhosis and chronic liver disease groups:

- Prior solid organ transplant.

- Previous or current cancer history within the past 5 years (excluding non-melanoma
skin cancer).
We found this trial at
5
sites
Rochester, Minnesota 55905
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5841 S Maryland Ave
Chicago, Illinois 60637
(773) 702-1000
Principal Investigator: Anjana Pillai, MD
Phone: 773-702-4477
University of Chicago Medical Center The University of Chicago Medicine has been at the forefront...
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4500 San Pablo Rd S
Jacksonville, Florida 32224
(904) 953-2000
Phone: 904-953-3464
Mayo Clinic Florida Thousands of people come to Mayo Clinic in Jacksonville, Fla., annually for...
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New York, New York 10065
Principal Investigator: Brett E. Fortune, MD, MSc
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Richmond, Virginia 23249
Principal Investigator: Binu John, MD, MPH
Phone: 804-675-5584
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Richmond, VA
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