Evaluation of VGX-3100 and Electroporation Alone or in Combination With Imiquimod for the Treatment of HPV-16 and/or HPV-18 Related Vulvar HSIL (Also Referred as: VIN 2 or VIN 3)



Status:Recruiting
Conditions:Infectious Disease
Therapuetic Areas:Immunology / Infectious Diseases
Healthy:No
Age Range:18 - Any
Updated:4/4/2019
Start Date:June 26, 2017
End Date:September 2021
Contact:Inovio Call Center
Email:clinical.trials@inovio.com
Phone:(267) 440-4237

Use our guide to learn which trials are right for you!

A Phase 2, Randomized, Open Label, Efficacy Study of VGX-3100 Delivered Intramuscularly Followed by Electroporation With CELLECTRA™ 2000 Alone or in Combination With Imiquimod, for the Treatment of HPV-16 and/or HPV-18 Related High Grade Squamous Intraepithelial Lesion (HSIL) of the Vulva

The purpose of this study is to test the safety and efficacy of an investigational
immunotherapy VGX-3100, in combination with a study device, to treat women with vulvar HSIL
(VIN 2 or VIN 3) associated with HPV types 16 and/or 18. VGX-3100 is being assessed as an
alternative to surgery with the potential to clear the underlying HPV infection. For more
information visit our study website at: www.VINresearchstudy.com


Inclusion Criteria:

- Women aged 18 and above;

- Have high grade squamous intraepithelial lesion (HSIL) of the vulva (VIN2 or VIN3)
caused by infection with HPV types 16 and/or 18 confirmed at screening visit;

Exclusion Criteria:

- Biopsy-proven differentiated VIN;

- Any previous treatment for vulvar HSIL within 4 weeks prior to screening;

- Allergy to imiquimod 5% cream or to an inactive ingredient in imiquimod 5% cream;

- Pregnant, breastfeeding or considering becoming pregnant within 6 months following the
last dose of investigational product;

- Immunosuppression as a result of underlying illness or treatment;

- Significant acute or chronic medical illness.
We found this trial at
21
sites
630 W 168th St
New York, New York
212-305-2862
Principal Investigator: Ana Tergas
Phone: 212-342-6895
Columbia University Medical Center Situated on a 20-acre campus in Northern Manhattan and accounting for...
?
mi
from
New York, NY
Click here to add this to my saved trials
3550 Jerome Avenue
Bronx, New York 10467
(718) 920-4321
Principal Investigator: Anne Van Arsdale
Phone: 718-405-8214
Montefiore Medical Center As the academic medical center and University Hospital for Albert Einstein College...
?
mi
from
Bronx, NY
Click here to add this to my saved trials
Jupiter, Florida 33458
Principal Investigator: Donna Pinelli
Phone: 561-263-5791
?
mi
from
Jupiter, FL
Click here to add this to my saved trials
1211 Medical Center Dr
Nashville, Tennessee 37232
(615) 322-5000
Principal Investigator: Ronald Alvarez
Phone: 800-811-8480
Vanderbilt Univ Med Ctr Vanderbilt University Medical Center (VUMC) is a comprehensive healthcare facility dedicated...
?
mi
from
Nashville, TN
Click here to add this to my saved trials
500 S State St
Ann Arbor, Michigan 48109
(734) 764-1817
Principal Investigator: Anthony Opipari
Phone: 734-763-5492
University of Michigan The University of Michigan was founded in 1817 as one of the...
?
mi
from
Ann Arbor, MI
Click here to add this to my saved trials
Augusta, Georgia 30912
Principal Investigator: Daron Ferris
Phone: 706-721-2535
?
mi
from
Augusta, GA
Click here to add this to my saved trials
Chattanooga, Tennessee 37403
Principal Investigator: Stephen DePasquale
Phone: 423-266-3636
?
mi
from
Chattanooga, TN
Click here to add this to my saved trials
1653 W. Congress Parkway
Chicago, Illinois 60612
(312) 942-5000
Principal Investigator: Summer Dewdney
Phone: 312-942-7254
Rush University Medical Center Rush University Medical Center encompasses a 664-bed hospital serving adults and...
?
mi
from
Chicago, IL
Click here to add this to my saved trials
Columbus, Ohio 43231
Principal Investigator: Milroy Samuel
Phone: 614-682-5182
?
mi
from
Columbus, OH
Click here to add this to my saved trials
969 Lakeland Drive
Jackson, Mississippi 39216
Principal Investigator: D. Paul Seago
Phone: 601-200-4974
?
mi
from
Jackson, MS
Click here to add this to my saved trials
Kalamazoo, Michigan 49009
Principal Investigator: Roger Beyer
Phone: 269-372-7800
?
mi
from
Kalamazoo, MI
Click here to add this to my saved trials
Kansas City, Kansas
Principal Investigator: Kevin Ault
Phone: 913-588-6287
?
mi
from
Kansas City, KS
Click here to add this to my saved trials
9200 W Wisconsin Ave
Milwaukee, Wisconsin 53226
(414) 805-3666
Principal Investigator: William Bradley
Phone: 414-805-4763
Froedtert and the Medical College of Wisconsin Froedtert Health combines with the Medical College of...
?
mi
from
Milwaukee, WI
Click here to add this to my saved trials
Newark, Delaware 19713
Principal Investigator: Mark Borowsky
Phone: 302-623-4450
?
mi
from
Newark, DE
Click here to add this to my saved trials
Newark, New Jersey 07103
Principal Investigator: Mark Einstein
Phone: 973-972-8367
?
mi
from
Newark, NJ
Click here to add this to my saved trials
1410 North 13th Street
Norfolk, Nebraska 68701
Principal Investigator: Keith Vrbicky
Phone: 605-232-9000
?
mi
from
Norfolk, NE
Click here to add this to my saved trials
1100 N. Lindsay
Oklahoma City, Oklahoma 73104
(405) 271-4000
Principal Investigator: Katherine Smith
Phone: 405-271-8001
University of Oklahoma The OU Health Sciences Center is composed of seven health-related colleges located...
?
mi
from
Oklahoma City, OK
Click here to add this to my saved trials
Pittsburgh, Pennsylvania 15213
Principal Investigator: Robert Edwards
Phone: 412-641-3578
?
mi
from
Pittsburgh, PA
Click here to add this to my saved trials
Rio Piedras, 00935
Principal Investigator: Josefina Romaguera
Phone: 787-245-8082
?
mi
from
Rio Piedras,
Click here to add this to my saved trials
Scarborough, Maine 04074
Principal Investigator: Christopher Darus
Phone: 207-396-8670
?
mi
from
Scarborough, ME
Click here to add this to my saved trials
Winston-Salem, North Carolina 27103
Principal Investigator: Robert Parker
Phone: 866-853-0220
?
mi
from
Winston-Salem, NC
Click here to add this to my saved trials