Oral Vancomycin for Preventing Clostridium Difficile Recurrence
| Status: | Enrolling by invitation |
|---|---|
| Healthy: | No |
| Age Range: | 18 - Any |
| Updated: | 9/2/2018 |
| Start Date: | June 8, 2017 |
| End Date: | June 2020 |
Secondary Prophylaxis With Oral Vancomycin for Clostridium Difficile Recurrence: A Randomized Control Study
This study evaluates the role of oral vancomycin in the prevention of recurrent Clostridium
difficile for hospitalized patients receiving systemic antibiotic therapy. Half of
participants will receive oral vancomycin daily, while the other half will receive a placebo.
difficile for hospitalized patients receiving systemic antibiotic therapy. Half of
participants will receive oral vancomycin daily, while the other half will receive a placebo.
Clostridium difficile colitis is a significant cause of morbidity and mortality among
hospitalized patients. Following the first episode, up to 15% of people experience recurrent
disease. A major risk factor for recurrent disease is exposure to systemic antibiotics.
Oral vancomycin given four times daily is one of the treatments for Clostridium difficile
infection; it is not known if giving oral vancomycin at a lower dose such as once daily may
help prevent recurrences. Oral vancomycin may be most helpful in preventing recurrences when
given to patients at greatest risk of recurrent disease, such as when they are receiving
systemic antibiotics.
To evaluate this, the investigators propose comparing the rates of recurrent Clostridium
difficile infection in patients who receive oral vancomycin with systemic antibiotics to when
patients take systemic antibiotics alone.
hospitalized patients. Following the first episode, up to 15% of people experience recurrent
disease. A major risk factor for recurrent disease is exposure to systemic antibiotics.
Oral vancomycin given four times daily is one of the treatments for Clostridium difficile
infection; it is not known if giving oral vancomycin at a lower dose such as once daily may
help prevent recurrences. Oral vancomycin may be most helpful in preventing recurrences when
given to patients at greatest risk of recurrent disease, such as when they are receiving
systemic antibiotics.
To evaluate this, the investigators propose comparing the rates of recurrent Clostridium
difficile infection in patients who receive oral vancomycin with systemic antibiotics to when
patients take systemic antibiotics alone.
Inclusion Criteria:
- Age 18 years and older
- Any history of Clostridium difficile infection based on a positive Clostridium
difficile stool test performed at a lab affiliated with Rochester Regional Health
System or patient report
- A new in-patient admission, with an antibiotic treatment plan for greater than 48
hours
Exclusion Criteria:
- Documented allergy and/or adverse drug reaction to vancomycin
- Pregnant
- Patients who are admitted with a current episode of Clostridium difficile infection
- Patients with total colectomy
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