MMRF Molecular Profiling Protocol



Status:Recruiting
Conditions:Blood Cancer, Hematology, Hematology
Therapuetic Areas:Hematology, Oncology
Healthy:No
Age Range:18 - Any
Updated:3/21/2019
Start Date:June 2015
End Date:June 2023
Contact:Jennifer Yesil, M.S.
Email:yesilj@themmrf.org
Phone:203.652.0237

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Clinical-grade Molecular Profiling of Patients With Multiple Myeloma and Related Plasma Cell Malignancies

Here we propose an "integrative sequencing approach" utilizing a 1500 gene exome comparative
analysis between multiple myeloma or related plasma cell malignancies and normal cells
coupled to capture transcriptome sequencing to provide a nearly comprehensive landscape of
the genetic alterations for the purpose of identifying informative and/or actionable
mutations in patients with multiple myeloma and plasma cell malignancies. The approach will
enable the detection of point mutations, insertions/deletions, gene fusions and
rearrangements, amplifications/deletions, and outlier expressed genes among other classes of
alterations.


Inclusion Criteria:

1. Patients must have a diagnosis of multiple myeloma or related malignancy

2. Patients are undergoing standard of care bone marrow aspirates

3. Patients (male or female) from any race or ethnicity must be at least 18 years of age
at the time of registration.

4. Procedure-specific signed informed consent form prior to initiation of any
study-related procedures.

Exclusion Criteria:

1. It is the enrolling study physician's discretion to decide if a patient is not fit
enough to undergo a bone marrow aspirate.

2. Patients who are incarcerated are not eligible to participate.

3. Women who are pregnant

4. Patients who have had another malignancy within the last five (5) years (except for
basal or squamous cell carcinoma, or in situ cancer of the cervix) where there is a
possibility to contaminate the bone marrow aspirate.
We found this trial at
20
sites
281 W. Lane Ave
Columbus, Ohio 43210
(614) 292-6446
Ohio State University The Ohio State University’s main Columbus campus is one of America’s largest...
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201 Dowman Dr
Atlanta, Georgia 30303
(404) 727-6123
Emory University Emory University, recognized internationally for its outstanding liberal artscolleges, graduate and professional schools,...
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Atlanta, GA
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185 Cambridge Street
Boston, Massachusetts 02114
617-724-5200
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Boston, MA
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5801 South Ellis Avenue
Chicago, Illinois 60637
 773.702.1234
University of Chicago One of the world's premier academic and research institutions, the University of...
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Chicago, IL
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4100 John R
Detroit, Michigan 48201
800-527-6266
Barbara Ann Karmanos Cancer Institute Karmanos is based in southeast Michigan, in midtown Detroit, and...
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Detroit, MI
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1 Gustave L Levy Pl # 271
New York, New York 10029
 (212) 241-6500
Mount Sinai Med Ctr Founded in 1852, The Mount Sinai Hospital is a 1,171-bed, tertiary-care...
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New York, NY
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500 S State St
Ann Arbor, Michigan 48109
(734) 764-1817
University of Michigan The University of Michigan was founded in 1817 as one of the...
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Ann Arbor, MI
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450 Brookline Ave
Boston, Massachusetts 2215
617-632-3000
Dana-Farber Cancer Institute Since it’s founding in 1947, Dana-Farber has been committed to providing adults...
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Boston, MA
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Charlotte, North Carolina 28211
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Charlotte, NC
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3310 Live Oak St
Dallas, Texas 75204
(214) 820-2687
Baylor Research Institute Baylor Research Institute (BRI) is a dedicated research center for finding prevention...
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Dallas, TX
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Duarte, California 91010
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Duarte, CA
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8503 Arlington Blvd., Ste. 400
Fairfax, Virginia 22031
(703) 280-5390
Virginia Cancer Specialists, PC Now the world's most advanced cancer treatment capabilities can be found...
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Fairfax, VA
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30 Prospect Ave
Hackensack, New Jersey 07601
(201) 996-2000
Hackensack University Medical Center Hackensack University Medical Center, part of the Hackensack University Health Network,...
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Jacksonville, Florida 32216
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Jacksonville, FL
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3322 West End Avenue
Nashville, Tennessee 37203
(615)329-SCRI (7274)
Sarah Cannon Research Institute Sarah Cannon Research Institute (SCRI) is a global strategic research organization...
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200 First Street SW
Rochester, Minnesota 55905
507-284-2511
Mayo Clinic Rochester Mayo Clinic is a nonprofit worldwide leader in medical care, research and...
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Rochester, MN
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Saint Louis, Missouri 63110
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San Francisco, California 94115
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5777 E Mayo Blvd
Scottsdale, Arizona 85259
(480) 515-6296
Mayo Clinic Scottsdale Mayo Clinic Arizona was the second Mayo practice to be established outside...
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Scottsdale, AZ
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Toronto,
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