COLLAGEN CROSS-LINKING WITH ULTRAVIOLET-A IN ASYMMETRIC CORNEAS



Status:Recruiting
Conditions:Ocular, Ocular, Dermatology, Dermatology
Therapuetic Areas:Dermatology / Plastic Surgery, Ophthalmology
Healthy:No
Age Range:8 - Any
Updated:10/14/2018
Start Date:December 21, 2016
End Date:January 1, 2020
Contact:Debi S Gravemann, RN
Email:dg@cxlusa.com
Phone:(314) 966-3377

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This study will assess changes in visual acuity and corneal symmetry after corneal collagen
cross-linking (CXL) of asymmetric corneas.

This study will evaluate the results of Corneal Collagen Crosslinking (CXL) in patients with
conditions that include keratoconus, forme fruste keratoconus, post-LASIK ectasia, pellucid
marginal degeneration, forme fruste pellucid marginal degeneration, diurnal fluctuation
post-radial keratotomy, or Terrien's marginal degeneration. This is an outcomes study, all
patients receive treatment.

Inclusion Criteria:

- A diagnosis of at least one of the following conditions:

1. Keratoconus

2. Forme fruste keratoconus

3. Post-LASIK ectasia

4. Pellucid marginal degeneration

5. Forme fruste pellucid marginal degeneration

6. Diurnal fluctuation post-radial keratotomy

7. Terrien's marginal degeneration

Exclusion Criteria:

1. Corneal thickness < 375 microns measured by ultrasound or Pentacam.

2. Contraindications or hypersensitivities to any study medications or their components.

3. Pregnancy or breastfeeding.

4. Any history of herpes simplex corneal disease in an eye to be treated.

5. Nystagmus or any other condition that would, in the judgement of the investigator,
prevent a steady gaze during the treatment.

6. Inability to cooperate with diagnostic tests.

7. Enrollment in another ophthalmic clinical trial.
We found this trial at
9
sites
Atlanta, Georgia 30328
Principal Investigator: Doyle Stulting, MD, PhD
Phone: 770-740-0233
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Brecksville, Ohio 44141
Principal Investigator: Shamik Bafna, MD
Phone: 216-503-6535
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Brecksville, OH
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Chicago, Illinois 60035
Principal Investigator: Randy Epstein, MD
Phone: 847-432-6010
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Chicago, IL
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Dallas, Texas 75231
Principal Investigator: Brad Bowman, MD
Phone: 214-692-0146
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Dallas, TX
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Hoffman Estates, Illinois
Principal Investigator: Parag A Majmudar, MD
Phone: 847-432-6010
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Hoffman Estates, IL
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Littleton, Colorado 80120
Principal Investigator: S. Lance Forstot, MD
Phone: 720-709-7533
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Littleton, CO
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Saint Louis, Missouri 63131
Principal Investigator: Gregg J Berdy, MD
Phone: 314-966-5000
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Saint Louis, MO
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San Francisco, California 94115
Principal Investigator: Dan Goodman, MD
Phone: 415-474-3333
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San Francisco, CA
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8416 E. Shea Blvd., Ste C-101
Scottsdale, Arizona 85260
Phone: 480-483-3937
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Scottsdale, AZ
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