Extension to the Study of Efficacy of CDZ173 in Patients With APDS/PASLI
| Status: | Recruiting |
|---|---|
| Healthy: | No |
| Age Range: | 12 - 75 |
| Updated: | 2/17/2019 |
| Start Date: | September 8, 2016 |
| End Date: | June 6, 2023 |
| Contact: | Novartis Pharmaceuticals |
| Email: | novartis.email@novartis.com |
| Phone: | 1-888-669-6682 |
An Open-label, Non-randomized Extension Study to Evaluate the Long Term Safety, Tolerability, Efficacy and Pharmacokinetics of CDZ173 in Patients With APDS/PASLI (Activated Phosphoinositide 3-kinase Delta Syndrome/p110δ-activating Mutation Causing Senescent T Cells, Lymphadenopathy and Immunodeficiency)
This study is designed to provide long-term CDZ173 treatment, a selective PI3Kδ inhibitor, to
the patients with genetically activated PI3Kδ, i.e., patients with APDS/PASLI who
participated in the CCDZ173X2201 study or who were treated previously with PI3Kδ inhibitors
other than CDZ173. The study is open-label designed to establish the long-term safety,
tolerability, efficay and pharmacokinetics of CDZ173 in the target population.
the patients with genetically activated PI3Kδ, i.e., patients with APDS/PASLI who
participated in the CCDZ173X2201 study or who were treated previously with PI3Kδ inhibitors
other than CDZ173. The study is open-label designed to establish the long-term safety,
tolerability, efficay and pharmacokinetics of CDZ173 in the target population.
Inclusion Criteria:
- Written informed consent must be obtained before any assessment is performed.
- Paients must have participated in the study CCDZ173X2201 or were treated previously
with PI3Kδ inhibitors other than CDZ173.
- Patients who are deemed by the Investigator to benefit from PI3Kδ inhibitor therapy.
- Patients or their legal representatives (for patients under the age of 18 years) must
be able to communicate well with the Investigator, to understand and comply with the
requirements of the study.
- Documented APDS/PASLI-associated genetic PI3K delta mutation.
Exclusion Criteria:
- Any medically significant disease or condition that is unrelated to APDS/PASLI
Other protocol-defined inclusion/exclusion criteria may apply.
We found this trial at
2
sites
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