Reduced Intensity (RIC) Conditioning And Transplantation of HLA-Haploidentical Related Hematopoietic

Inclusion Criteria:

- Karnofsky performance status of ≥70% or Lansky play score ≥ 70%

- A related haploidentical bone marrow donor with up to 2 or 3 HLA locus-mismatches

- The donor and recipient must be HLA identical for at least one haplotype (using high
resolution DNA based typing) at the following genetic loci: HLA-A, HLA-B, HLA-C, and
HLA-DRB1.

- Adequate liver and renal function

- Absence of decompensated congestive heart failure, or uncontrolled arrhythmia and left
ventricular ejection fraction ≥ 40%

- Diffusion capacity corrected (DLCOcorr) > 40% predicted, and absence of O2
requirements

- > 6 months after prior autologous transplant (if applicable)

- Agrees to use contraception during study treatment

- Voluntary written consent (adult or parent/guardian with presentation of the minor
information sheet, if appropriate)

Exclusion Criteria:

- < 70 years with an available 5-6/6 HLA-A, B, DRB1 matched sibling donor

- Pregnancy or breastfeeding

- Evidence of HIV infection or known HIV positive serology

- Current active and uncontrolled serious infection

- Acute leukemia in morphologic relapse/persistent disease defined as > 5% blasts in
normocellular bone marrow OR any % blasts if blasts have unique morphologic markers
(e.g. Auer rods).

- CML in blast crisis

- Large cell lymphoma, mantle cell lymphoma and Hodgkin disease that is progressive on
salvage therapy.

- stable non-bulky disease is acceptable.

- Active central nervous system malignancy

Criteria For Donor Selection:

- Donors must be HLA-haploidentical relatives of the patient, defined as having a shared
HLA haplotype between donor and patient at HLA-A, -B, -C, and -DRB1.

- Eligible donors (14-70 years old) include biological children, siblings or half
siblings, or parents, able and willing to undergo bone marrow harvesting.

- For donors <18 years, the maximum recipient weight (actual body weight) should not
exceed 1.25 times the donor weight (actual body weight)1 In addition, bone marrow
product volume should be limited to 20 ml/kg donor weight for donors <18 years.