Chronic Inflammation and Exercise Responsiveness
| Status: | Recruiting |
|---|---|
| Conditions: | Endocrine |
| Therapuetic Areas: | Endocrinology |
| Healthy: | No |
| Age Range: | 30 - 55 |
| Updated: | 11/8/2018 |
| Start Date: | March 2016 |
| End Date: | December 2019 |
| Contact: | Ian R Lanza, PhD |
| Email: | lanza.ian@Mayo.edu |
| Phone: | 507-255-8147 |
The purpose of this study is to determine how chronic inflammation influences skeletal muscle
protein metabolism and metabolic function in humans. The investigators will evaluate acute
responsiveness to a single bout of exercise in men and women who are either lean or
overweight/obese. The investigators will explore the relationship between circulating
inflammatory markers and anabolic, proteomic, and transcriptional responses to acute
exercise. The investigators will measure skeletal muscle protein synthesis in the
postabsorptive state and in response to a single bout of exercise.
protein metabolism and metabolic function in humans. The investigators will evaluate acute
responsiveness to a single bout of exercise in men and women who are either lean or
overweight/obese. The investigators will explore the relationship between circulating
inflammatory markers and anabolic, proteomic, and transcriptional responses to acute
exercise. The investigators will measure skeletal muscle protein synthesis in the
postabsorptive state and in response to a single bout of exercise.
Inclusion Criteria:
- Age 30-55 years
- BMI 19-45 kg/m2
Exclusion Criteria:
- Anemia (female subjects hemoglobin of <11 g/dl and male subjects hemoglobin <12 g/dl)
- Active coronary artery disease or history of unstable macrovascular disease (unstable
angina, myocardial infarction, stroke, and revascularization of coronary, peripheral
or carotid artery within 3 months of recruitment)
- Renal insufficiency/failure (serum creatinine > 1.5mg/dl)
- Oral warfarin group medications or history of blood clotting disorders.
- Pregnancy or breastfeeding
- Alcohol consumption greater than 2 glasses/day or other substance abuse
- Untreated or uncontrolled thyroid disorders
- Debilitating chronic disease (at the discretion of the investigators)
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