Prospective Registry of Multiplex Testing (PROMPT)



Status:Recruiting
Healthy:No
Age Range:18 - Any
Updated:3/2/2019
Start Date:January 2016
End Date:January 2020
Contact:Mark Robson, MD
Phone:646-888-4058

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Prospective Registry of Multiplex Testing (PROMPT): Phase II

This study is being done to learn more about how changes in certain genes may be linked to
cancer. Some people with cancer got their disease because they inherited an abnormal
(mutated) gene.

The researchers of this study want to better understand the risks that are linked to genetic
changes in these less well-studied genes. By understanding these risks, we believe that
doctors will be able to give better advice to families with mutations in these genes.

PROMPT (Prospective Registry of Multiplex Testing) is an Internet-based, patient-directed
ascertainment study. It is a partnership between Memorial Sloan Kettering, University of
Pennsylvania, Mayo Clinic, and Dana Farber Cancer Institute in collaboration with Ambry
Genetics, GeneDx, Myriad Genetics, Pathway Genomics, and Quest Laboratories (5 laboratories
providing multiplex panel testing commercially).

Inclusion Criteria:

- Individual with deleterious (pathogenic) or likely deleterious (likely pathogenic)
mutation in a cancer susceptibility gene OR

- Individual with a variant of uncertain significance (VUS) in a cancer susceptibility
gene OR

- Family members, either tested or not tested, who are part of a family known to be
transmitting a deleterious or likely deleterious mutation or a variant of uncertain
significance in a cancer predisposition gene

Exclusion Criteria:

- Inability or refusal to participate in consent discussion

- Subject is less than 18 years old
We found this trial at
10
sites
1000 North Village Avenue
Rockville Centre, New York 11570
Phone: 646-888-4058
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136 Mountainview Boulevard
Basking Ridge, New Jersey 07920
Phone: 646-888-4058
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Basking Ridge, NJ
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450 Brookline Ave
Boston, Massachusetts 2215
617-632-3000
Dana-Farber Cancer Institute Since it’s founding in 1947, Dana-Farber has been committed to providing adults...
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Boston, MA
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650 Commack Rd
Commack, New York 11725
(631) 623-4000
Phone: 646-888-4058
Memorial Sloan-Kettering Cancer Center at Commack Memorial Sloan Kettering Cancer Center - the world's oldest...
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Commack, NY
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Harrison, New York
Phone: 646-888-4058
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Harrison, NY
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480 Red Hill Road
Middletown, New Jersey 07748
Phone: 646-888-4058
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Middletown, NJ
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225 Summit Avenue
Montvale, New Jersey 07645
Phone: 646-888-4058
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Montvale, NJ
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1275 York Ave
New York, New York 10021
(212) 639-2000
Principal Investigator: Mark Robson, MD
Phone: 646-888-4058
Memorial Sloan Kettering Cancer Center Memorial Sloan Kettering Cancer Center — the world's oldest and...
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New York, NY
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3451 Walnut St
Philadelphia, Pennsylvania 19104
1 (215) 898-5000
Univ of Pennsylvania Penn has a long and proud tradition of intellectual rigor and pursuit...
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Philadelphia, PA
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200 First Street SW
Rochester, Minnesota 55905
507-284-2511
Phone: 507-538-3270
Mayo Clinic Cancer Center The Mayo Clinic Cancer Center is a National Cancer Institute-designated comprehensive...
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Rochester, MN
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