Computer-Based Intervention in HIV-Positive Young Adults

Depression frequently occurs in young adults with HIV infection. When young adults with HIV
experience depression, they are less likely to take their prescribed antiretroviral therapy
(ART). When HIV occurs simultaneously with depression, individuals are more likely to have
indicators in their blood that are linked risk for developing other illnesses in the future.
The purpose of this project is to examine the ability of an avatar-based intervention,
called eSMART-MH, to decrease depressive symptoms in HIV-positive depressed young adults.

Inclusion Criteria:

- 23-53 years of age

- Fluent in English

- Be able to view images and text on a computer screen and hear audio using a headset

- Have a diagnosis of unipolar depression or have significant depressive symptoms noted
in the electronic medical record (EMR) or referred to the study by a provider at the
Grady Ponce de Leon Clinic because of their depressive symptoms

- Receive care at Ponce de Leon Center and at least 1 scheduled HIV medical appointment
in the last 6 months

- Reside in the Atlanta, Georgia area

- Have a valid telephone number and email address

- Answer all items correctly on consent post-test

Exclusion Criteria:

- Diagnosis of bipolar depression

- Deaf, blind or unable to understand spoken English

- Currently pregnant, history of pregnancy within the last year or plan to become
pregnant within the next 4 months

- Plan to move from the Atlanta, Georgia area within four months of study enrollment

- Taking corticosteroids or disease-modifying anti-rheumatic drugs

- If on antidepressant medication, taking it for less than 1 month

- Fail to pass post-consent test after three attempt