Effect of Luteal Progesterone Support on Pregnancy Rates With Combined Clomid/ Gonadotropin & IUI

To determine the difference in clinical pregnancy rates with and without luteal progesterone
support in a young reproductive aged population having undergone ovulation induction with
combined clomiphene citrate and gonadotropin protocol with intrauterine insemination.

Patients will be randomized in a treatment arm or control arm. The treatment arm receives
the luteal progesterone support and the control arm does not. Each arm will have 260
patients.

Inclusion Criteria:

- Age 18-37

- BMI 19-34 kg/m2

- Day 2-3 Follicle stimulating hormone (FSH) less than 10IU/mL

- Estradiol (E2) less than 80 pg/mL

- Anti-mullerian hormone (AMH) more than 1.5 ng/mL; or antral follicle count (AFC) up
to 10

- Two patent fallopian tubes confirmed by hysterosalpingogram (HSG) or
chromopertubation

- Normal uterine cavity confirmed by HSG, saline sonohysterogram (SIS) or hysteroscopy

Exclusion Criteria:

- Severe male factor (total count less than 10 million sperm)

- Systemic diseases not limited to diabetes

- Pregnancy within 3 months

- More than 1 prior cycle of gonadotropin treatment

- Any ovarian cyst >15mm that has persisted for > 1 month

- Endometrioma and/or Endometriosis-stage III or IV

- Submucosal uterine fibroids; untreated endometrial polyps >1 cm;abnormal reproductive
tract bleeding

- Intolerance or allergy to study drug

- Substance abuse (including alcohol and tobacco)

- History of chemotherapy (except for gestational conditions) or radiotherapy

- Minors and those adults not capable of consenting on their own