Breakfast Intake and Satiety Hormones
| Status: | Recruiting |
|---|---|
| Conditions: | Obesity Weight Loss |
| Therapuetic Areas: | Endocrinology |
| Healthy: | No |
| Age Range: | 18 - 44 |
| Updated: | 4/21/2016 |
| Start Date: | September 2015 |
| End Date: | April 2016 |
| Contact: | Nikhil Dhurandhar, Ph.D. |
| Email: | nikhil.dhurandhar@ttu.edu |
| Phone: | 806-834-6446 |
Does Higher Protein Quality Breakfast Reduce Energy Intake When Following a Weight Loss Diet Plan?
The experiments in this study will assess if while following a reduced energy diet, eating a
breakfast with higher protein quality will enhance weight loss compared to another breakfast
with lower protein quality, but matched for energy density and macronutrient composition.
breakfast with higher protein quality will enhance weight loss compared to another breakfast
with lower protein quality, but matched for energy density and macronutrient composition.
There will be 2 experiments in this pilot study. Both will be randomized crossover study
designs with subjects beginning on either an egg breakfast of higher protein quality or
cereal breakfast of lower protein quality, and reversing to receive the breakfast not
previously ingested. The subjects will consume breakfasts under supervision at our clinic on
all days of the study, except for weekends. Subjects will be advised to continue eating
their breakfast at home on weekends. All subjects will receive weight loss counseling and
follow a weight loss diet for 2 weeks. Experiment 1 will test the hypothesis that when on a
reduced calorie diet, intake of an egg breakfast compared to cereal breakfast increases
satiety, reduces lunch time energy consumption and reduces dinner time energy consumption in
clinical and free living condition. Insulin, glucagon-like peptide-1, peptide YY 3-36,
ghrelin, plasma glucose, baseline and post intervention anthropomorphic measurements, and
hunger questionnaires completed during the consumption of both breakfasts and subsequent
meals will be compared. Experiment 2 will compare the effects of the two breakfasts on
intake of foods considered tempting or highly palatable, and assessment of energy intake
pre/post test lunch followed by offering brownies. It is hypothesized that consumption of an
egg breakfast compared to cereal breakfast, will help in reducing intake of foods considered
tempting.
designs with subjects beginning on either an egg breakfast of higher protein quality or
cereal breakfast of lower protein quality, and reversing to receive the breakfast not
previously ingested. The subjects will consume breakfasts under supervision at our clinic on
all days of the study, except for weekends. Subjects will be advised to continue eating
their breakfast at home on weekends. All subjects will receive weight loss counseling and
follow a weight loss diet for 2 weeks. Experiment 1 will test the hypothesis that when on a
reduced calorie diet, intake of an egg breakfast compared to cereal breakfast increases
satiety, reduces lunch time energy consumption and reduces dinner time energy consumption in
clinical and free living condition. Insulin, glucagon-like peptide-1, peptide YY 3-36,
ghrelin, plasma glucose, baseline and post intervention anthropomorphic measurements, and
hunger questionnaires completed during the consumption of both breakfasts and subsequent
meals will be compared. Experiment 2 will compare the effects of the two breakfasts on
intake of foods considered tempting or highly palatable, and assessment of energy intake
pre/post test lunch followed by offering brownies. It is hypothesized that consumption of an
egg breakfast compared to cereal breakfast, will help in reducing intake of foods considered
tempting.
Inclusion Criteria:
- Calculated BMI of 25.0-39.9 kg/m2
- Sedentary (< 3 hours/week of moderate intensity physical activity)
- Otherwise healthy
Exclusion Criteria:
- ≥5% body weight loss or gain in the three months preceding the study
- Post-menopausal (has not had period for 12 months)
- Plans to begin an exercise program or change current exercise routines between
initiation of study and final study
- Anyone following a medical diet prescription
- Anyone with a chronic disease including type II diabetes, hypothyroidism,
hypoparathyroidism, cardiovascular disease, cancer of any type
- Health conditions and chronic illness that contraindicate behavioral weight loss
treatment using a low calorie diet
- Anyone who is currently pregnant, or lactating
- Medications that may influence or inhibit appetite, sensory functioning, or hormone
signaling
- Plans to begin taking any supplements that may influence weight loss
- Report of medical condition or surgical intervention that affects swallowing or
chewing ability
- Anyone with a pacemaker or other internal medical device
- Any practicing vegans or vegetarians
- Any practicing gluten-free diet
- Allergy, aversion, or dislike to any of the foods offered for meals
We found this trial at
1
site
Click here to add this to my saved trials
