Regulation of Postprandial Nitric Oxide Bioavailability and Vascular Function By Dairy Fat
| Status: | Recruiting |
|---|---|
| Conditions: | Endocrine, Diabetes |
| Therapuetic Areas: | Endocrinology |
| Healthy: | No |
| Age Range: | 18 - 50 |
| Updated: | 4/21/2016 |
| Start Date: | March 2016 |
| End Date: | April 2017 |
| Contact: | Richard S Bruno, PhD, RD |
| Phone: | 614-292-1698 |
Cardiovascular disease (CVD) is the leading cause of death in the United States. Short-term
increases in blood sugar, or postprandial hyperglycemia (PPH), affect blood vessel function
and increase the risk of CVD. Greater intakes of dairy foods have been associated with a
lower risk of CVD, but whether these effects occur directly or indirectly by displacing
foods in the diet that might increase CVD risk is unclear. Further controversial is the
extent to which dietary fat derived from dairy foods regulate the risk of CVD. The health
benefits of dairy on CVD risk are at least partly attributed to its ability to limit PPH and
resulting PPH-mediated responses leading to vascular dysfunction. This provides rationale to
investigate full-fat containing dairy as a dietary strategy to reduce PPH and risk for heart
disease. The objective of this project is to define the extent to which full-fat dairy milk
compared to non-fat dairy milk protects against PPH-induced vascular dysfunction by reducing
oxidative stress responses that limit nitric oxide bioavailability to the vascular
endothelium in adults with prediabetes.
increases in blood sugar, or postprandial hyperglycemia (PPH), affect blood vessel function
and increase the risk of CVD. Greater intakes of dairy foods have been associated with a
lower risk of CVD, but whether these effects occur directly or indirectly by displacing
foods in the diet that might increase CVD risk is unclear. Further controversial is the
extent to which dietary fat derived from dairy foods regulate the risk of CVD. The health
benefits of dairy on CVD risk are at least partly attributed to its ability to limit PPH and
resulting PPH-mediated responses leading to vascular dysfunction. This provides rationale to
investigate full-fat containing dairy as a dietary strategy to reduce PPH and risk for heart
disease. The objective of this project is to define the extent to which full-fat dairy milk
compared to non-fat dairy milk protects against PPH-induced vascular dysfunction by reducing
oxidative stress responses that limit nitric oxide bioavailability to the vascular
endothelium in adults with prediabetes.
This study consists of three, 3-hour postprandial trials in response to consuming the
following dietary treatments: 1. oral glucose challenge, 2. oral glucose challenge in
combination with non-fat milk, and 3. oral glucose challenge in combination with whole milk.
For three days preceding each trial, participants will be provided all meals to standardize
physiologic responses to test meals. On each trial day, vascular function will be assessed
and blood samples collected prior to and at 30 minute intervals for 3 hours following test
meal ingestion.
following dietary treatments: 1. oral glucose challenge, 2. oral glucose challenge in
combination with non-fat milk, and 3. oral glucose challenge in combination with whole milk.
For three days preceding each trial, participants will be provided all meals to standardize
physiologic responses to test meals. On each trial day, vascular function will be assessed
and blood samples collected prior to and at 30 minute intervals for 3 hours following test
meal ingestion.
Inclusion Criteria:
1. hemoglobin A1c 5.7-6.4%
2. non-dietary supplement user
3. no medications affecting vasodilation, inflammation, or energy metabolism
4. no CVD
5. nonsmokers
6. individuals having blood pressure <140/90 mmHg and total cholesterol <240 mg/dL
Exclusion Criteria:
1. unstable weight (±2 kg)
2. vegetarian or dairy allergy
3. alcohol intake >3 drinks/day or >10 drinks/week
4. ≥ 7 hours/week of aerobic activity
We found this trial at
1
site
Ohio State University The Ohio State University’s main Columbus campus is one of America’s largest...
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